HBVM阳性肺结核病人用利福喷丁或利福平治疗肝功能损害观察

目的 观察利福喷丁?利福平对HBVM 阳性肺结核病人肝功能的影响?方法 对HBVM 阳性和阴性肺结核病人分别用利福喷丁和利福平治疗,观察治疗前后肝功能损害情况?结果 利福平组较利福喷丁组出现肝损害多( P< 0-01) ;HBVM 阳性较阴性病人易出现肝损害( P< 0-01) ;利福平组HBVM 阳性较阴性病人出现肝损害多( P< 0-01) ;利福喷丁组HBVM 阳性和阴性肝损害发生率无显著差异( P> 0-05) ?结论 抗结核治疗时HBVM 阳性比阴性病人更易发生肝损害,与其用药前即存在肝病理损害有关,治疗肺结核用利福喷丁比利福平疗效好且安全?

Observation of the effect on liver function in pulmonary tuberculosis with positive HBVM treated with rifapentine or rifampicin

Objective To evaluate the effect on liver function in pulmonary tuberculosis with positive HBVM treated with rifapentine or rifampicin.Method In HBVM positive group and negative group treated with rifapentine or rifampicin,liver function injury were observed before and after treatment.Results The incidence of liver injury in treated rifampicin group is higher than that in treated rifapentine group( P <0 01).The incidence of liver injury in HBVM positive group is higher than that in HBVM negative group( P <0 01).In treated rifampicin group,the incidence of liver injury in HBVM positive group is higher than that in HBVM negative group( P <0 01).In treated rifapentine group showed liver injury no significant differences( P >0 05).Conclusion The incidence of liver injury in HBVM positive group is higher than that in HBVM negative group because liver injury exists in the former before treatment.In the treatment of pulmonary tuberculosis,using rifapentine is better and safer.