| 心肌肌浆网Ca~(2+)-ATP酶研究进展 |
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| 引用本文： | 李晓梅,马依彤. 心肌肌浆网Ca~(2+)-ATP酶研究进展[J]. 医学综述, 2008, 14(17): 2570-2573 |
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| 作者姓名： | 李晓梅 马依彤 |
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| 作者单位： | 新疆医科大学第一附属医院心脏中心,乌鲁木齐,830054 |
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| 基金项目： | 新疆维吾尔自治区高校科研计划创新研究群体基金 |
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| 摘 要： | 在正常心肌舒张期,心肌肌浆网Ca2+-ATP酶(SERCA2a)将Ca2+从胞质中摄回肌浆网中,在心肌肥厚、心力衰竭等病理生理过程中有多条信号通路对SERCA2a进行调节,使其活性和表达量下调。通过转基因及药物治疗上调SERCA2a的表达,可能会成为心力衰竭等疾病治疗的新手段。
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| 关 键 词： | 心肌肌浆网Ca~(2+)-ATP酶 心力衰竭 心肌肥厚 信号通路 |
Research Advances in SERCA2a |
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| LI Xiao-mei,MA Yi-tong. Research Advances in SERCA2a[J]. Medical Recapitulate, 2008, 14(17): 2570-2573 |
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| Authors: | LI Xiao-mei MA Yi-tong |
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| Affiliation: | LI Xiao-mei,MA Yi-tong.(Department of Cardiology,the First Affiliated Hospital,Xinjiiang Medical University,Urumqi 830054,China) |
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| Abstract: | The Sarco/Endoplasmic Reticulum Ca2+-ATPase2a(SERCA2a)transports Ca2+ inside the SR lumen during relaxation of the normal cardiac myocyte.Serval signaling pathways have been demonstrated to be involved in regulation of SERCA2a in pathophysiological process in hypertrophy and failing hearts,which may down-regulate activity and expression levels of SERCA2a.It may be a new strategy to treat uncompensated cardiac hypertrophy and heart failure by upregulation of expression levels of SERCA2a using transgene and d... |
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| Keywords: | Sarco/Endoplasmic Reticulum Ca~(2+)-ATPase(SERCA2a) Heart failure Hypertrophy Signaling pathway |
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