自身免疫性甲状腺炎与排卵障碍相关性研究

目的 探讨自身免疫性甲状腺炎（AIT）在多囊卵巢综合征（PCOS）与非PCOS排卵障碍患者中的发生情况。方法 收集2012年1月至2013年12月在绍兴市妇幼保健院就诊的排卵障碍者，其中PCOS196例，非PCOS排卵障碍152例，同期因男方因素就诊而卵巢排卵正常者104例为对照组。比较各组甲状腺功能、甲状腺抗体与甲状腺超声检查结果。结果 PCOS组、非PCOS排卵障碍组、正常对照组中AIT的发生率分别为19.9%、7.9%及6.7%，PCOS组与其他两组间比较差异均有统计学意义（P＜0.05）；非PCOS排卵障碍组与正常对照组间差异无统计学意义（P＞0.05）。PCOS组促甲状腺素（TSH）、抗甲状腺过氧化物酶抗体（TPOAb）、抗甲状腺球蛋白抗体(TgAb)均显著高于其余两组（P＜0.05）。各组间超声阳性结果差异无统计学意义（P＞0.05）。结论 AIT在PCOS患者中的发生率高于非PCOS排卵障碍者及正常者；PCOS可能是一种与AIT相关的自身免疫性疾病。

Association of autoimmune thyroiditis with ovulation failure.

Abstract： Objective To investigate the association of autoimmune thyroiditis with ovulation failure. Methods All outpatients with ovulation failure who visited Women and Children’s Hospital of Shaoxing from Jan 2012 to Dec 2013 were enrolled in the study .A total of 196 of them were diagnosed with PCOS and another 152 patients were non-PCOS. Totally 104 patients with normal ovulation whose infertility was caused by husbands at the same period were enrolled as controls. Thyroid function ,thyroid autoantibodies and ultrasound thyroid scan were compared among the three groups. Results Significantly higher prevalence of AIT was detected in PCOS(19.9%) patients when compared to non-PCOS(7.9%) and control group(6.7%)( P＜0.05）. Moreover there was no difference between non-PCOS and controls (P＞0.05）. Elevated serum thyrotrophin (TSH), anti-thyroid peroxidase antibodies (TPOAb) and antithyroglobulin antibodies(TgAb) in PCOS were revealed when compared with non-PCOS and controls (P<0.05). The positive rate of ultrasound thyroid scan in all subjects did not differ significantly(P＞0.05）.Conclusion The prevalence of AIT in PCOS patients are significantly higher than that in ovulation failure patients without PCOS and in controls,which suggests PCOS may be a kind of autoimmune disease and has close association with AIT.