酸化豆粉对大鼠降血脂和抗氧化作用的影响

目的研究酸化豆粉对大鼠降血脂和抗氧化作用的影响。方法将SD雄性大鼠根据体重和血胆固醇水平分为3组,普通饲料对照组、高脂饲料组及10%酸化豆粉组,饲养6周后,测定大鼠空腹血脂、载脂蛋白及抗氧化指标水平的变化。结果酸化豆粉可显著降低大鼠血清低密度脂蛋白胆固醇、总胆固醇、甘油三脂及血清载脂蛋白B浓度,增高高密度脂蛋白胆固醇及血清载脂蛋白A水平,同时增高载脂蛋白A/载脂蛋白B比值;酸化豆粉组大鼠血清超氧化物歧化酶、谷胱甘肽过氧化物酶及血清硒水平显著升高,脂质过氧化产物水平显著降低。结论酸化豆粉预防大鼠高血脂及抗氧化作用明显,提示酸化豆粉有成为心血管保健食品的潜力和意义。

Effects of acidificated soybean powder on blood lipid and antioxidation in rats

Objective To study the effect of acidificated soybean powder on rats blood lipid and antioxidation.Methods According to weights and blood cholesterol leval,male SD rats were divided into three groups:ordinary contrast group,high fat contained group and 10% acidificated soybean powder contained group.After six-week feeding stage,the change of serum lipid,apolipoprotein and antioxidation system level were observed in rats.Results Acidificated soybean powder significantly reduced low-density lipoprotein cholesteral(LDL-C),total cholesteral(TC),triglyceride(TG) and serum apoB level,increased high-density lipoprotein cholesteral(HDL-C) and serum apoA level as well as apoA/apoB rate.The serum surperoxide dismutase(SOD),glutathione peroixdase(GSH-Px) and Se level in acidificated soybean powder contained group were significantly higher than those of other groups,and malondialdehyde(MDA) level was significantly lower.Conclusion Acidificated soybean powder was able to reduce rats blood lipid and antioxodate.It had the probable future to be a vascular-disease-protected food.