| 羟丙基-β-环糊精对冬凌草二萜类成分的包合作用 |
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| 引用本文： | 刘培丽,杨琳琳,王永圣,高燕,张玉龙,崔福德. 羟丙基-β-环糊精对冬凌草二萜类成分的包合作用[J]. 沈阳药科大学学报, 2006, 23(9): 557-561 |
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| 作者姓名： | 刘培丽 杨琳琳 王永圣 高燕 张玉龙 崔福德 |
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| 作者单位： | 沈阳药科大学,药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的研究羟丙基-β-环糊精(HPCD)在溶液中对冬凌草二萜类成分的包合作用。方法采用相溶解度法进行研究。结果在水溶液中,冬凌草甲素的浓度随HPCD浓度的增加而呈线性增加,为典型的AL型相溶解度图。在不同pH值、不同温度、不同离子强度等条件下计算包合表观稳定常数。包合过程的热力学参数为:ΔH=17.31 kJ.mol-1,ΔS=39.57 J.mol-1,且不同温度条件下的ΔG均小于零。结论羟丙基β环糊精可以提高冬凌草甲素的溶解度。HPCD与冬凌草甲素形成摩尔比为1∶1的包合物,包合过程为吸热过程,而且是自发进行。
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| 关 键 词： | 羟丙基-β-环糊精 冬凌草甲素 包合物 相溶解度 热力学参数 |
| 文章编号： | 1006-2858(2006)09-0557-05 |
| 收稿时间： | 2005-12-15 |
| 修稿时间： | 2005-12-15 |
Effect of inclusion of rubescens total diterpenoids-HP-β-cyclodextrin |
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| LIU Pei-li,YANG Lin-lin,WANG Yong-sheng,GAO Yan,ZHANG Yu-long,CUI Fu-de. Effect of inclusion of rubescens total diterpenoids-HP-β-cyclodextrin[J]. Journal of Shenyang Pharmaceutical University, 2006, 23(9): 557-561 |
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| Authors: | LIU Pei-li YANG Lin-lin WANG Yong-sheng GAO Yan ZHANG Yu-long CUI Fu-de |
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| Abstract: | Objective To investigate the complexation of rubescens total diterpenoids(RTD) with hydroxpropy-β-cyclodextrin(HPCD) in aqueous solution.Methods The experiment was preformed by the phase-solubility method.Results The solubility of oridonin(ORI) increased linearly with the increase of HPCD concentration in various aqueous sloutions,which showed typical A_L-type phase solubility profile.The apparent stability constant at different pH values,temperatures and ion strengths was calculated respectively.Thermodynamic parameters during the inclusion process were as follows:ΔH=17.31 kJ·mol~(-1),ΔS=39.57 J·mol~(-1),ΔG<0.Conclusions ORI solubility in water can be improved by introducing HPCD into the system.Based on the stoichiometric analysis,the molecular ratio of the ORI/HPCD complex is 1∶1.The complex process is endothermic and spontaneous. |
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| Keywords: | hydroxpropy-β-cyclodextrin oridonin inclusion compound phase-solubility thermodynamic parameters |
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