丹红注射液对急性冠脉综合征患者介入治疗术后炎性因子、血脂变化及早期心脏事件的影响

目的观察丹红注射液对急性冠脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)前后血清炎症反应标志物血清超敏反应蛋白(hs-CRP)、内皮素(ET)、纤维蛋白原(Fg)、低密度脂蛋白胆固醇(LDL-C)水平的影响,并探讨PCI治疗后加用丹红注射液治疗与早期心脏相关事件的关系。方法选择在我院行PCI治疗的91例患者,术后随机分为两组,对照组入院时给予常规治疗,丹红注射液组(治疗组)在常规治疗基础上加用丹红注射液静滴4周。所有患者于PCI前1d、术后第2d、术后4周分别测定hs-CRP、ET、Fg、血脂,并观察心脏事件发生率。结果两组hs-CRP、ET、Fg,在PCI术后第2d即明显升高,4周后炎性因子均低于术后2d(P<0.01),治疗组低于对照组(P<0.05),并且治疗组与对照组相比心脏事件发生率有降低的趋势(P=0.315)。结论ACS患者PCI术后应用丹红注射液可以有效抑制炎性因子的产生,明显降低LDL-C,可减少早期心脏事件的发生。

The Effect of Danhong Injection on Cardiovascular Event in earlier Period and Inflammatory Reaction of the Patients of ACS with PCI

Objective To observe the effect of Danhong injection on marks of blood-serum Inflammatory reaction of the patients of ACS with PCI.To discuss the relationship between the use of Danhong injection and the cardiovascular event in the earlier period after PCI.Methods 91 patients with PCI in our hospital from June 2004 to June 2007 were divided randomly into two groups.The control group was treated with the conventional therapy,and the treatment group was treated with intravenous drip of Danhong injection for 4 weeks besides the conventional therapy.Test the hs-CRP,ET,Fg,Blood-fats three times(the day before PCI,the second day after PCI and 4 weeks later) and observe the incidence rate of the cardiovascular event.Results The levels of inflammatory reactions of two groups increased obviously in the second day after PCI,and decreased obviously 4 weeks later.The level of the treatment group was lower than that of the control group 4 weeks later.The incidence rate of the cardiovascular event has a tendency to become lower in the treatment group than that in the control group.Conclusion Danhong injection used in the patients of ACS after PCI can inhibit inflammatory reaction,cut down the level of LDL-C and reduce the cardiovascular event.