肺癌患者血清氧自由基清除剂含量的测定

同时检测了７２例原发性肺癌、３３例肺良性疾病和３５例健康人血清中总超氧化物歧化酶（Ｔ－ＳＯＤ）、铜锌超氧化物歧化酶（ＣｕＺｎ－ＳＯＤ），锰超氧化物歧化酶（Ｍｎ－ＳＯＤ），铜蓝蛋白（ＣＰ）活力及尿酸（ＵＡ）含量。肺癌血清Ｍｎ－ＳＯＤ及ＵＡ水平显著高于肺良性疾病和健康组（Ｐ＜０．０１）。Ｍｎ－ＳＯＤ对肺癌诊断的敏感性为８６．１１％，特异性为９１．１８％，诊断正确率为８８．５７％。晚期肺癌患者Ｍｎ－ＳＯＤ活力高于早期病人（Ｐ＜０．０５），８例肺癌手术后Ｔ－ＳＯＤ及Ｍｎ－ＳＯＤ明显下降（Ｐ＜０．０１）。Ｍｎ－ＳＯＤ与ＵＡ并联检测敏感性为９４．４４％，特异性为８５．２９％，诊断正确率为９０％。Ｍｎ－ＳＯＤ、ＵＡ和ＣＰ全部测定时敏感性则为９７．２２％，特异性为７７．９４％，诊断正确率为８７．８６％。结果提示，肺癌患者血清氧自由基清除剂水平增高。对肺癌诊断、鉴别诊断、病情分析及手术疗效监测起重要作用。

Determination of Serum Scavengers-Oxygen Radicals in Patients with Carcinoma of the Lung

The activity of T-SOD, CuZn-SOD, Mn-SOD, ceruloplasmin and the content of uric acid were determined in 72 patients with lung cancer, in whom 8 cases the amount before and afrer operation were compared as those of 33 patients with benign lung disease and 35 cases of normal healthy adults. It was found that the activity of serum T-SOD in patients with lung cancer or benign lung disease was higher than that of normal healthy subjects(P<0.05).The activity of serum MnSOD, ceruloplasmin and the content of serum uric acid in patients with lung cancer were higher than those of patients with benign lung disease and normal heathy subjects (P<0. 01).The sensitivity, specificity and the diagnostic accuracy rates of MnSOD for lung cacer were 86. 11%, 91. 18%, 88. 57% respectively. The mean activity of Mn-SOD in patients with advanced lung cancer was significantly higher than that of patients with early lung cancer(P<0.05).The activity of Mn-SOD and T-SOD decreased markdely after removal of lung cancer(P<0.01).Combining Mn-SOD with uric adid increased the sensitvity, specificity and the diagnostic accuracy rates for lung cancer to 94.44%, 85. 29%, 90% respectively.It is suggested that tha levels of serum scavengers-oxygen radicals in patients with lung cancer when increased will optimize their value in the diagnosis as well as differential diagnosis of lung cancer from other lung disease. Thir determination might be helpful in the following monitoring after operation for lung cancer patients.