直肠癌患者手术前后血可溶性P选择素和TNF水平检测的临床意义

目的:探讨直肠癌患者手术治疗前后血可溶性P选择素和TNF水平的变化及临床意义。方法:分别应用放免法和ELISA法测定了34例直肠癌患者手术治疗前血可溶性P选择素和TNF含量,并与30名正常健康人作比较。结果:直肠癌患者手术治疗前后血可溶性P选择素和TNF水平非常显著地高于正常人组(P<0.01),手术治疗后一年,复发组又非常明显地高于未复发组(P<0.01)。结论:测定直肠癌患者手术治疗前后血可溶性P选择素和TNF水平检测的变化与直肠癌患者的病情和预后密切相关,均具有重要的临床价值。

Clinical Significance of Determination of Changes of Blood P-selectin and TNF Levels After Operation in Patients with Rectal Cancer

Objective To study the clinical significance of changes of blood P-selectin and TNF levels after operation in patients with rectal cancer. Methods Serum TNF (with RIA) and plasma P-selectin (with ELISA) levels were determined in 34 patients with rectal cancer both before and after operation as well as in 35 controls. Results Before operation, blood P-selectin and TNF levels were significantly the higher in the patients than those in controls (P<0.01). Twenty-two of the 30 patients underwent operation showed no sign of recurrence at 1 year and their blood P-selectin and TNF levels dropped to within normal range. Hower in the 8 patients with recurrence, blood levels of P-selectin and TNF remained abnormally high (vs those without recurrence, P<0.01). Conclusion Blood P-selectin and TNF levels were closely related to the disease process of rectal cancer and were of prognostic values.