结直肠癌同时性肝转移的手术疗效分析

目的探讨结直肠癌同时性肝转移的外科治疗临床疗效。方法收集自2001年2月至2008年2月诊治的86例结直肠癌伴同时性肝转移患者的临床资料,分析同时手术和异时手术患者的临床资料,对比2组患者1、3、5年的生存率。结果 2组肝转移瘤直径、肝转移瘤数目、肝转移瘤分布、术前血清CEA和肝功能Child-Pugh分级等临床资料比较差异无统计学意义(P均>0.05);同时手术组1、3、5年累积生存率为80.3%、39.7%、13.8%;异时手术组患者1、3、5年累积生存率为78.7%、38.9%、14.1%,2组生存率无明显统计学差异(P均>0.05)。结论结直肠癌同时性肝转移的患者,行同时手术与异时手术疗效相似,在条件允许的情况下应行同时手术治疗。

The efficacy of resections of colorectal cancer with synchronous liver metastasis:an analysis of outcomes on simultaneous versus separate resections

Objective To investigate the curative effects of simultaneous versus metachronous resections for colorectal cancer with synchronous liver metastasis.Methods The clinical data of 86 patients with colorectal cancer complicating synchronous liver metastasis and received simultaneous or separate hepatectomy and primary colorectal lesions resections between February 2001 and February 2008 were recruited in present study.The 1-,3-and 5-year cumulative survival rates were compared in simultaneous resections(synchronous group,n=47)and separate resections(metachronous group,n=39).Results There were no significant differences in the basic data including the diameter,the number and the distribution of liver metastasis tumors,serum carcinoembryonic antigen(CEA) before operation and Child-pugh class of liver function between two groups(all P>0.05).There were no significant differences in the 1-,3-and 5-year cumulative survival rates between synchronous group and metachronous group(80.3%,39.7%,13.8% vs 78.7%,38.9%,14.1%;all P>0.05).Conclusions Due to having similar survival rates in simultaneous and metachronous resections,the patients with colorectal cancer complicating synchronous liver metastasis should receive simultaneous hepatectomy and resection of primary colorectal cancer if their body’s condition is permitted.