(18)~F-FDG PET/CT和MRI对鼻咽癌诊断价值的比较

目的： 比较18F-FDG PET/CT和MRI在鼻咽癌TNM分期中的诊断价值，阐明18F-FDG PET/CT 标准化摄取值（SUV）与鼻咽癌T分期和病理类型的关系。方法：41例鼻咽癌患者行18F-FDG PET/CT全身扫描，且于3周内行头颈部MRI检查。按照国际通用的美国癌症联合委员会(AJCC)鼻咽癌TNM分期标准对病变分别行MRI、PET/CT分期,并将组织病理结果作为参照标准。结果：①原发肿瘤：PET/CT诊断鼻咽癌T分期的准确率为85.37%，MRI的准确率为60.98%，两者比较差异有显著性（U=2.49，P< 0.05）；结合病理结果提示，PET/CT降低分期3例，提高分期7例；鼻咽癌患者原发灶SUV值与鼻咽癌T分期呈明显正相关关系（rs=0.706，P<0.05）。未分化癌患者SUV值明显高于低分化鳞癌，两组间比较差异有显著性（t=7.89，P<0.05）。②淋巴结转移：41例患者共切取淋巴结139枚，其中PET/CT正确判断阳性72枚，阴性56枚，灵敏度和特异度分别为93.51%和90.32%；MRI正确判断阳性60枚，阴性51枚，灵敏度和特异度分别为80.00%和79.69%；PET/CT诊断淋巴结转移的准确率为92.09%，MRI诊断淋巴结转移的准确率为79.86%，两者比较差异有显著性（U=2.93，P< 0. 05）。③远处转移：41例患者18F-FDG PET/CT全身扫描结果中，2例患者出现肝脏和骨骼远处转移灶，而MRI因扫描部位的限制未能显示。结论：18F-FDG PET/CT对鼻咽癌的TNM分期较MRI更全面、可靠。

Comparison of diagnostic value between ~(18)F-FDG PET/CT and MRI in nasopharyngeal carcinoma

Objective To determine whether the use of 18F-FDG PET/CT alters staging and management of nasopharyngeal carcinoma (NPC) when compared with MRI staging practice;and to explore the relation of standard uptake value (SUV) of 18F-FDG PET/CT and the pathological classification and T staging of NPC. Methods The study was performed retrospectively on a group of 41 patients with a new diagnosis of NPC. All the patients underwent whole body PET/CT scanning and head & neck MRI scanning within 3 weeks of each other. ...