两项指标联合检测早期急性冠状动脉综合征的应用

目的 通过对心型脂肪酸结合蛋白(H-FABP)、心肌肌钙蛋白I(cTnI)两项指标的联合检测为早期急性冠状动脉综合征(ACS)的诊断提供可靠依据.方法 应用全自动化学发光、生化分析仪及配套试剂对40例胸痛开始在0～6 h、6～12 h、12 h 3个时间段的ACS患者血清中的H-FABP、cTnI的值进行检测.结果 cTn1在40例ACS患者发作0～6 h测得阳性率为55%,H-FABP在40例ACS患者发作0～6 h测得阳性率为85%,2项指标联合分析阳性率可达92.5%.而且在12 h内的几个时段所测得的结果灵敏度在联合检测上都相应提高了很多.结论 H-FABP与cTnI联合检测对ACS早期诊断具有高灵敏性.

The application of combined detection of two indexes on early acute coronary syndrome

Objective To provide the dependable data on diagnosis for acute coronary syndrome(ACS) through combined detection of H-FABP and the cTnI.Methods The cTnI and H-FABP in the serum of the 40 patients was detected three times:on admission(≤6 hours from the chest pain onset),>6-12 hours and after next 12 hours by automatic biochemistry analyzer.Results During 6 hours the positive rates of cTnI,H-FABP were 55%,85% respectively in 40 patients of ACS.The positive rate of combined detection was 92.5%.And the result sensitivity of combined detection was also enhancement(≤12 hours from the chest pain onset).Conclusion The combined detection of the H-FABP and the cTnI is sensitive for the early diagnosis for ACS.