不育男性患者精浆 Ig A 型抗精子抗体对精液参数的影响

目的探讨精浆IgA型抗精子抗体(anti‐sperm antibody ,AsAb)对精液参数的影响.方法用酶联免疫吸附试验(ELISA)检测191例不育男性患者精浆的IgA型AsAb ,据此分为阳性和阴性两组,将两组患者的精液主要参数进行比较分析.结果精浆IgA型AsAb阳性组患者精子的密度、精子活率、精子总活力(PR+ NP)明显低于阴性组患者,差异具有统计学意义(P<0.01);两组患者的精液正常形态精子百分率差异无统计学意义(P>0.05).结论精浆IgA型AsAb不影响精液正常形态精子百分率,但能使精子的密度、活率、总活力明显降低,是导致男性不育的重要因素之一.

Effect of scmen antisperm antibody IgA on main parameters of semen in male infertility patients

Objective To study the effects of the semen antisperm antibody IgA（AsAb） on the main parameters of semen.Methods Sperm samples obtained from 191 patients of male infertility were selected and divided into the semen AsAb positive and negative groups by ELISA method.A comparison among the semen items including the sperm density,sperm activity rate and total activity（PR＋NP） were performed between the two groups.Results The sperm density,sperm activity rate and the sperm total activity（PR＋NP） in the semen AsAb positive group were lower than those in the semen AsAb negative group with statistical difference between them（P〈0.01）.The percentage of normal morphology sperms in the AsAb positive group had no statistics difference in comparison with the AsAb negative group（P〉0.05）.Conclusion Semen AsAb IgA has no influence on the percentage of normal morphology sperms,but can decrease the sperm density,sperm activity rate and the total activity（PR＋NP）,which is one of the important factors resulting in the male infertility.