尿酸与高敏C-反应蛋白联合检测在心血管疾病方面的应用

目的研究尿酸(UA)与高敏C-反应蛋白(hs-CRP)的血清高水平表达与心血管疾病中冠状动脉病变的关系。方法选择34例UA、hs-CRP均正常的冠心病患者为对照组,78例单纯尿酸增高患者为试验组A,94例UA增高合并hs-CRP增高患者为试验组B,根据冠状动脉造影结果比较3组别冠状动脉的狭窄程度及病变累计血管支数。结果 3组别冠状动脉造影冠状动脉狭窄程度两两比较,经卡方检验χ2分别为6.39、25.69、39.20,P值均小于0.05,差异有统计学意义;3组冠状动脉造影病变累及冠状动脉血管支数两两比较,经卡方检验χ2分别为7.48、8.12、22.3,P值均小于0.05,差异有统计学意义。结论 UA与hs-CRP与冠状动脉病变存在密切的关系,UA与hs-CRP的血清水平可作为冠心病严重程度的一个评估指标。

The application of combined detection of uric acid and high sensitivity C-reactive protein on cardiovascular disease

Objective To study the relationship of serum high-level expression of the uric acid（UA）,high sensitivity C-reactive protein（hs-CRP） and cardiovascular disease.Methods 34 patients with coronary heart disease were as the control group（with normal levels of UA,hs-CRP） and 78 patients with high uric acid as the test group A,94 patients with UA and hs-CRP levels increased as a test group B.According to the results of coronary angiography,we compared the degree of coronary artery stenosis and vascular lesions of the cumulative count in three groups.Results The result showed that the degree of coronary artery stenosis in three groups was significantly different（χ2 were 6.39,25.69,39.20,P〈0.05）;and vascular lesions of the cumulative count in three groups was significantly different（χ2 were 7.48,8.12,22.3,P〈0.05）.Conclusion There is a close relationship among UA,hs-CRP and cardiovascular disease,and UA,hs-CRP serum levels can be used as an assessment indicators of the severity of coronary heart disease.