抗-CCP抗体与RF联合检测对类风湿关节炎的诊断价值

目的探讨抗环瓜氨酸肽(CCP)抗体与类风湿因子(RF)联合检测对类风湿关节炎(RA)的诊断价值。方法选取RA患者184例(RA组)、非RA患者76例(非RA组)、健康对照组30例为研究对象,用酶联免疫吸附试验(ELISA)法检测抗CCP IgG型抗体,免疫比浊法检测RF,比较单项和两项联合检测对RA诊断的敏感度和特异性。结果RA患者的抗CCP抗体和RF阳性率分别为77.7%和76.09%;串联方式的特异性高(96.22%),但敏感度(60.32%)减低;并联方式的敏感度(93.48%)明显提高,但特异性(39.67%)较低。结论联合检测抗CCP抗体和RF可提高RA诊断的准确性。

Diagnostic value of combined detection of Anti-CCP antibody and RF for rheumatoid arthritis diagnosis

Objective To investigate the diagnostic value of combined detection of anti-cyclic citruilinated pep tide（CCP） antibody and rheumatoid factor（RF） for rheumatoid arthritis（RA） diagnosis. Methods 18%. patients with RA（RA group）,76 patients with non-RA（non-RA group）,and 30 cases undergo heahh examination（control group） were enrolled. Anti-CCP IgG antibody was detected by ELISA, and rheumatoid faetor（RF） was detected by rate nephelometry. The sensitivities and specificities of single detection and combined detection of anti-CCP antibody and RF were analyzed. Results The positive rates of anti-CCP antibody and RF in the RA group were 77.7 % and 76.1 respectively. Parallel combined detection had higher specificity（96.22% ）, but lower sensitivity（60.32 % ）. However, parallel combined detection had higher sensitivity（93.48%）,but lower specificity（39.67%）. Conclusion Combined detection of anti-CCP antibodies and RF can improve the RA diagnostic accuracy.