乙醇依赖患者血清中肝功能变化的临床研究

目的测定血清中丙氨酸氨基转移酶(ALT )、天门冬氨酸氨基转移酶(AST )、碱性磷酸酶(ALP)、谷氨酰转移酶(GGT )、乳酸脱氢酶(LDH)、总胆红素(TBil)、直接胆红素(DBil)、间接胆红素(IBil),以检测乙醇对肝脏的损害.方法空腹抽取62例乙醇依赖患者和65例健康人员静脉血,分离出血清,在全自动生化分析仪上测定肝功能指标.结果乙醇依赖患者 ALT 、AST 、ALP 、GGT 、LDH 值分别为(68.5±8.6)、(63.2±8.1)、(183.6±11.6)、(64.5±6.7)、(276.0±26.9)U /L ,TBil 、DBil 、IBil 值分别为(31.9±6.5)、(14.3±7.1)、(17.6±5.9)μmol/L ,比健康对照组有显著增高(P<0.01).结论乙醇依赖患者血清中肝功能指标显著升高,对其进行合理的干预和治疗,可防止患者长期饮酒对肝功能的进一步损害.

Clinical research of changes of liver function in patients with alcohol dependence

Objective To determine serum liver function(ALT,AST,ALP,GGT,LDH,T-bil,D-bil) and other indicators for detecting liver damage caused by alcohol.Methods venous blood samples of 62 patients with alcohol dependence and 65 healthy persons were detected by the automatic biochemistry analyzer for determination of liver function indices.Results Patients with alcohol dependence with ALT,AST,ALP,GGT,LDH,TBil,DBil,IBil were(68.5±8.6)U/L,(63.2±8.1)U/L,(183.6±11.6)U/L,(64.5±6.7)U/L,(276.0±26.9)U/L,(31.9±6.5)μmol/L,(14.3±7.1) μmol/L,(17.6±5.9)μmol/L,these significantly increased than normal control group(P<0.01).Conclusion Liver function indices of patients with alcohol dependence would increase.The reasonable treatment and intervening way can protect the liver function.