CCP抗体、AKA和RF检测对类风湿关节炎早期诊断的临床价值

目的比较环瓜氨酸肽抗体（anti-cyclic citrulline peptide,CCP抗体）、抗角蛋白抗体（anti-keratin an-tibody,AKA）和类风湿因子（rheumatoid factor,RF）检测对类风湿关节炎（rheumatoid arthritis,RA）早期诊断的临床价值。方法收集来医院就诊的临床诊断具有类风湿关节炎的患者61例,健康体检者70例,CCP抗体采用ELISA法,AKA用间接免疫荧光法,RF采用免疫散射比浊法。结果单指标检测,CCP抗体对RA的敏感性为72.13%,优于AKA及RF（P〈0.01）;三指标联合检测敏感性可提高至95.08%,并且敏感性和特异性之和最大。结论三指标联合检测对于筛查和辅助诊断早期RA有重要意义。

Clinical value of CCP antibody,AKA and RF detection in early diagnosis of rheumatoid arthritis

Objective To compare the clinical value of CCP antibody,AKA and serum RF detection in the early diagnosis of rheumatoid arthritis(RA).Methods 61 patients with rheumatoid arthritis and 70 healthy physical examination persons were detected CCP antibody by ELISA,RF by turbidimetric immunoassay and AKA by indirect immunofluorescence.Results The sensitivity of CCP antibody to RA was 72.13% and better than that of AKA and RF(P<0.01).The sensitivity of the combination detection of CCP,RA and AKA was increased to 95.08% and the sum of sensitivity and specificity was biggest.Conclusion The combined determination of CCP antibody,RF and AKA level has important significance to screening and assisted diagnosis of early RA.