奥美拉唑和枸橼酸铋钾治疗消化性溃疡患者的临床疗效观察

目的观察和探讨奥美拉唑加枸橼酸铋钾胶囊治疗消化性溃疡的临床疗效。方法将2008年8月至2010年8月经胃镜确诊的幽门螺杆菌(HP)阳性消化性溃疡患者164例随机分为治疗组和对照组,其中治疗组88例,口服奥美拉唑和枸橼酸铋钾胶囊;对照组76例口服奥美拉唑、阿莫西林和甲硝唑。结果两组患者在症状消失、溃疡愈合和HP根除率方面差异无统计学意义(P>0.05);但在消化道不良反应方面,治疗组出现口干、便秘9例,占1.02%;对照组有32例出现不同程度的恶心、呕吐、厌食、纳差等消化道不良症状,占42.2%,两组患者比较差异有统计学意义(P<0.05)。结论奥美拉唑加枸橼酸铋钾胶囊组合的疗效好,消化道不良反应小,是治疗消化性溃疡比较理想的药物组合选择。

Clinical curative effect of omeprazole plus Livzon dele in treatment of peptic ulcer

Objective To observe clinical curative effect of omeprazole plus Livzon dele in treatment of peptic ulcer.Methods From Aug.2008 to Aug.2010,164 cases with helicobacter pylori（HP） positive peptic ulcer by gastroscopic were randomly divided into treatment group and control group.88 cases was treatment group treated byoral administration of omeprazole and livzondele.76 cases was control group treated by oral omeprazole,amoxicillin and metronidazole.Results Symptoms in two groups disappeared,ulcer healed and HP eradicate rates had no significant difference（P〉0.05）.But in the gastrointestinal adverse reactions,9 cases（1.02%） in treatment group were thirsty and constipated.32 cases（42.2%） in control group vomitted,hated food,lacked of appetite,there was significantly different between two groups（P〈0.05）.Conclusion Treatment of omeprazole plus Livzon dele has good curative effect with less gastrointestinal adverse reactions,it is useful way for peptic ulcer.