4种肿瘤标志物联合检测在宫颈鳞癌患者中的临床应用

目的探讨鳞状细胞癌相关抗原(SCC)、细胞角蛋白CK19(CyFRA21-1)、组织多肽特异抗原(TPS)、癌胚抗原(CEA)在宫颈鳞癌患者中的临床应用。方法分别采用化学发光法测定SCC含量,电化学发光法测定CEA、CyFRA21-1含量,酶联免疫吸附试验测定TPS含量,本研究共检测了65例患者(其中宫颈鳞癌52例,宫颈上皮内癌变13例)和30例健康者的SCC、CyFRA21-1、TPS、CEA的水平,数据用SPSS软件进行分析。结果宫颈癌组SCC、CyFRA21-1、TPS、CEA水平和敏感性均高于宫颈上皮内癌变组和健康对照组,差异具有统计学意义(P<0.05);SCC联合CyFRA21-1、TPS、CEA检测可显著提高宫颈鳞癌的敏感性、特异性及诊断的准确性。结论 SCC联合CyFRA21-1、TPS、CEA检测有助于宫颈鳞癌的辅助诊断,在临床上有一定的应用价值。

The clinical application of combined detection of four tumor markers in patients with cervical squamous cell carcinoma

Objective To investigate the value of the serum levels of squamous cell carcinoma（SCC）,cytokeratin-19-fragments（CYFRA21-1）,tissue polypeptide specific antigen（TPS） and carcinombryonic antigen（CEA） in patients with cervical squamous cell carcinoma.Methods SCC were measured by Chemiluminescence immunoassay,CYFRA21-1 and CEA were measured by electro-chemiluminescence immunoassay,and TPS was measured by enzyme-linked immunosorbent assay.Levels of SCC,CyFRA21-1,TPS,CEA30 in healthy females,13 patients with cervical inteaepithelial neoplasia and 52 patients with cervical squamous cell carcinoma were detected,and analyzed by SPSS software.Results The levels and positive rates of SCC,CYFRA21-1 and TPS in patients with cervical squamous cell carcinoma were significantly higher than those of health femals and cervical inteaepithelial neoplasia（P〈0.05）.The sensitivity,specivity and accuraty were increaed with combination of SCC＋CYFRA21-1＋CEA＋TPS.Conclusion There is sepecifically clinical applicated valuation of combined detection of the four tumor markers for diagnosis of cervical squamous cell carcinoma.