孕产妇传染性疾病血清标志物检测及临床意义

目的 了解本地妊娠妇女传染性疾病的感染情况,探讨妊娠妇女传染性疾病血清标志物检测的临床意义.方法 对2010年门诊和2 456例住院妊娠妇女进行产前乙型肝炎表面抗原(HBsAg)、丙型肝炎抗体(抗-HCV)、艾滋病病毒1/2抗体抗-HIV(1/2)]、梅毒抗体、TORCH-IgM型抗体弓形虫(TOX-IgM)、风疹病毒(RV-IgM)、巨细胞病毒(CMM-IgM)、单纯疱疹病毒(HSV-Ⅱ-IgM)]检测.结果 2 456例妊娠妇女中,孕产妇总阳性453例,阳性率18.44%,HBsAg阳性率14.08%,抗-HCV阳性率0.325%,抗-HIV(1+2)初筛阳性率0.122%,梅毒(TRUST/TPPA)阳性率0.977 %;TORCH IgM抗体总阳性率为2.93%,其中TOX-IgM、RV-IgM、CMV-IgM、HSV-Ⅱ- IgM的检出率分别为0.610%、0.203%、1.221%、0.895%.结论 对孕产妇进行产前传染性疾病血清标志物的检测,能够及早发现阳性患者,采取治疗和有效干预措施,防止母婴垂直传播,降低胎儿宫内感染,对提高优生优育水平有着重要的意义.

The detection on serum markers of pregnant women with infectious diseases and its clinical significance

Objective To understand the infection situation of pregnant women with infectious diseases,and discuss clinical significance of the detection on serum markers of maternal infectious disease.Methods 2 456 patients from our hospital in 2010 were collected,and levels of hepatitis B surface antigen（HBsAg）,HCV antibody,HIV（1/2） antibody,syphilis antibody,the TORCH-IgM type antibody（toxoplasma gondii TOX-IgM,rubella virus RV-IgM,cytomegalovirus CM-IgM V,herpes simplex virus HSV-Ⅱ-IgM） were tested.Results 453 out of 2 456 cases were positive（18.44%）.The positive rates of HBsAg and HCV antibody were 14.08%,0.325%.The early screening positive rate of HIV（1/2） antibody was 0.122%,and positive rate of syphilis（TRUST/TPPA） was 0.977%;total positive rate of TORCH IgM antibody was 2.93%,and detection rates of TOX-IgM,RV-IgM,CMV-IgM,HSV-Ⅱ-IgM were 0.610%,0.203%,1.221%,0.895%.Conclusion The detection on serum markers of pregnant women with infectious diseases could help finding the positive patients early,and taking therapy and effective intervention measures to prevent the maternal and infant perpendicular transmission,and reduce intrauterine fetal infection,and improve the level of eugenic and superior nurture.