略阳地区肝功能水平调查结果分析

目的了解略阳地区健康体检人群的肝功能水平分布情况及其变化趋势,为建立基于该地区的肝功水平参考区间奠定试验基础。方法以略阳地区健康体检人群为调查分析对象,采取新鲜血清标本,用西门子AD-VIL 1650全自动生化分析仪对肝功6项:丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)、总蛋白(TP)、清蛋白(ALB)进行检测。结果略阳地区健康体检人群的ALT、AST、TBIL、DBIL、TP、ALB为偏态分布。分析表明,ALT、AST、TBIL、DBIL水平在男女之间存在的差异有统计学意义(P<0.05),而TP、ALB水平在男女之间的差异无统计学意义(P>0.05)。ALT和AST的血清浓度都是随着年龄的增长先升高后降低。TBIL和DBIL的血清浓度在40岁之后随着年龄的增长而增高。TP和ALB的血清浓度则基本保持不变。结论略阳地区健康体检人群的ALT、AST、TBIL、DBIL水平在男女之间存在差异,在不同年龄段之间也存在差异,而TP、ALB不同性别和年龄段之间无明显差异。建议对体检人群进行健康评估时应区分不同性别和年龄段。

Analysis on survey results of liver function levels in Lueyang area

Objective To understand the distribution and the change trends of the liver function levels among the healthy people in Lueyang area to provide the experimental basis for establishing the regional reference intervals of the liver function levels. Methods Taking healthy people in Lueyang area as the subjects for survey and analysis, the fresh serum samples were collected and detected 6 items of liver function by the Mindray ADVIL 1650 automatic biochemical analyzer. Results Alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, total bilirubin （TBIL）, direct dilirubin （DBIL）, total protein （TP） and albumin（ALB） all showed the skewed distribution in the healthy people in Lueyang area. Analysis showed that the levels of ALT, AST, TBIL and DBIL appeared statistical difference between males and females（P〈0.05）. But the levels of TP and ALB had no statistical difference between males and females（P〉0.05）. Serum ALT and AST concentrations were increased firstly,then decreased with age in- crease. Serum TBIL and DBIL concentrations were increased after 40 years old with age increasing. Serum TP and ALB concentrations kept basially unchanged. Conclusion Among the healthy people in Lueyang area, the levels of ALT,AST,TBIL and DBIL have difference between men and women,so does among different age groups, but the levels of TP and ALB have no significant difference between different genders and among different age groups. So it is suggested tba~. conducting the health assessment on physical examination population should distinguish different gen- ders and different age groups.