急性脑梗死患者血清基质金属蛋白酶-9超敏C-反应蛋白与颈总动脉内膜中层厚度的相关性

目的 通过观察急性脑梗死(ACI)患者血清基质金属蛋白酶-9(MMP-9)、超敏C-反应蛋白(hs-CRP)水平变化,探讨其与颈总动脉内膜中层厚度(IMT)的相关性.方法 分别采用酶联免疫吸附法(ELISA)及超敏乳胶增强免疫比浊法检测185例ACI患者和45例健康对照组血清MMP-9、hs-CRP水平.结果 (1)ACI患者血清MMP-9、hs-CRP水平显著高于健康对照组(P＜0.01);颈动脉斑块形成组显著高于颈动脉内膜增厚组及颈动脉内膜正常组(P＜0.01);颈动脉内膜增厚组显著高于颈动脉内膜正常组(P＜0.01);颈动脉内膜正常组显著高于健康对照组(P＜0.01).且血清MMP-9、hs-CRP水平随着IMT值增大而升高.(2)ACI患者血清MMP-9、hs-CRP与IMT值呈显著正相关(r=0.357、0.409,P＜0.01),且血清MMP-9与hs-CRP呈显著正相关(r=0.415,P＜0.01),其相关性良好.结论 联合检测血清MMP-9、hs-CRP水平,可作为判断ACI患者疾病严重程度、临床疗效及评估预后的重要参数.

The correlation of serum MMP-9,hs-CRP and carotid artery IMT in patients with acute cerebral infarction

Objective To observe the serum MMP-9 and hs-CRP′s level change in patients with acute cerebral infarction（ACI）,and discuss their correlation with carotid artery IMT.Methods By ELISA method and latex enhancement immunity turbidimetric method respectively,the serum levels of MMP-9 and hs-CRP in 185 patients with ACI and 45 healthy people were tested.Results（1）Serum levels of MMP-9 and hs-CRP in ACI patients were significantly higher than those in control group（P〈0.01）,and serum levels of MMP-9 and hs-CRP in carotid plaques formation group were higher than those of carotid intimal hyperplasia group and carotid intima normal group（P〈0.01）,and those of carotid intimal hyperplasia group were higher than those of carotid intima normal group（P〈0.01）,and those of carotid intima normal group were higher than those of control group（P〈0.01）.The serum levels of MMP-9 and hs-CRP increased with the rise of IMT value.（2） The serum levels of MMP-9 and hs-CRP in patients with ACI had a positive correlation to IMT values（r=0.357,0.409,P〈0.01）,and serum level of MMP-9 had a positive correlation to serum level of hs-CRP（r=0.415,P〈0.01）.Conclusion The serum levels of MMP-9 and hs-CRP in patients with ACI were significantly higher than those in the control group,which have a positive correlation to IMT values.Combined detection on serum MMP-9 and hs-CRP′s level can be important parameters to judge illness severity,clinical curative effect and prognosis evaluation in patients with ACI.