过敏性结膜炎导致干眼症的临床分析

目的分析过敏性结膜炎的泪膜功能变化,探讨其与干眼症的相关性。方法取2012年1～5月福建省老年医院眼科门诊诊断为过敏性结膜炎的患者48例(96只眼)为观察组。取无全身疾患、干眼症和眼表疾患50例(100只眼)为对照组,分别进行裂隙灯检查、泪河线的测量、泪膜破裂时间检查、泪液分泌试验、角膜荧光素染色试验。结果左眼与右眼4个指标间均存在相关性;过敏性结膜炎组的BUT和FL评分与对照组差异有统计学意义(P<0.05);过敏性结膜炎组泪液分泌功能与泪河线高度之间存在相关性,泪膜破裂时间与FL染色评分之间存在相关性。结论过敏性结膜炎会引起泪膜稳定性异常,导致干眼症的发生。泪膜功能改变与疾病的严重程度有关。

Clinical analysis of xerophthalmia caused by allergic conjunctivitis

Objective To analyze the change of the tear film function in allergic conjunctivitis and to investigate its correlation with xerophthalmia.Methods 48 patients（96 eyes） with allergic conjunctivitis from January to May 2012 were taken as the observation group and 50 cases（100 eyes） without systematic diseases,xerophthalmia and ocular surface diseases were taken as the control group.Slit-lamp examinations,tear meniscus high（TMH）,break-up time（BUT）,Schirmer I test（Sit） and fluorescein（FL） were performed in these two groups.Results In both groups,right eyes were correlated with left eyes in TMH,Sit,BUT and FL.In the observation group,Sit was correlated with TMH,and BUT was correlated with FL.The tear film function of the patients with allergic conjunctivitis was changed.BUT and FL had statistical difference as compared with the control group.Conclusion The allergic conjunctivitis could decrease the stability of the tear film,and also lead to dry eye.Allergic conjunctivitis often occurs at both eyes,and the change of the tear film is correlated with the severity of allergic conjunctivitis.