肿瘤特异生长因子、CA19-9联合检测对腹水鉴别诊断的意义

目的探讨肿瘤标志物肿瘤特异生长因子（TSGF）、CA19-9联合检测在良、恶性腹水鉴别诊断中的临床意义。方法采集有腹水患者的血清和腹水样本各142例,其中恶性腹水患者32例,良性腹水患者112例,用免疫法及化学发光法检测患者血清和腹水TSGF、CA19-9的含量。结果恶性腹水组血清TSGF、CA19-9的阳性率分别为77.6%和67.0%,腹水TSGF、CA19-9的阳性率分别为87.5%和84.37%;其中,肿瘤标志物TSGF、CA19-9血清及腹水的阳性率明显高于良性腹水组,差异有统计学意义（P〈0.01）;两组含量的检测也得出相似的结果。联合检测血清TSGF、CA19-9诊断恶性腹水的敏感度为93.7%,特异度为97.8%。结论肿瘤标志物TSGF、CA19-9联合检测,对腹水的鉴别诊断有较好的临床价值。

Significance of combined detection of TSGF and CA19-9 for differential diagnosis of ascites

Objective To investigate the clinical significance of combination detection of tumor marker tumor specific growth factor(TSGF) and CA19-9 in the differential diagnosis of ascites.Methods Each 142 specimens of serum and ascites were collected from the patients with ascites,including 32 cases of malignant ascites and 112 cases of benign ascites.The immunoassay and chemiluminescence method were adopted to detect the levels of TSGF and CA19-9 in serum and ascites.Results The positive rates of serum TSGF and CA19-9 in the malignant ascites group were 77.6% and 67.0%,which in ascites were 87.5% and 84.37%,respectively.Among them,the positive rates of TSGF and CA19-9 in serum and ascites in the malignant acites group were significantly higher than those in the benign ascites group,difference showed statistical significance(P<0.01).The content detection in 2 groups also showed the similar results.In the combined detection of serum TSGF and CA19-9,the sensitivity for the diagnosis of malignant ascites was 93.7% and the specificity was 97.8%.Conclusion The combined detection of tumor marker TSGF and CA19-9 has better value to the differential diagnosis of ascites.