Isolated noncompaction of the ventricular myocardium in a patient presenting with subarachnoid hemorrhage

ObjectiveHyperhomocysteinemia and protein C deficiency have synergistic effect on the onset of thrombotic disease.MethodsWe report a 42-year old woman with myocardial infarction and venous thrombosis in whom recognition of heterozygous MTHRF gene mutation, hyperhomocysteinemia, and protein C deficiency.ResultsThe patient was treated successfully with coronary artery bypass graft surgery and systemic anticoagulation.ConclusionsOur report emphasize that a combined hyperhomocysteinemia, and protein C deficiency may be a high risk factor for arterial and venous thromboembolic events in young adults. These patients might be candidates for indefinite anticoagulation.