Phase II study of intensive chemotherapy with autologous bone marrow transplantation in patients in complete remission of disseminated breast cancer |
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Authors: | E. G. E. de Vries S. Rodenhuis H. C. Schouten P. S. G. J. Hupperets W. V. Dolsma J. V. Lebesque G. H. Blijham M. Bontenbal N. H. Mulder |
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Affiliation: | (1) Department of Medical Oncology, University Hospital Groningen, The Netherlands;(2) Department of Radiotherapy, University Hospital Groningen, The Netherlands;(3) Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands;(4) Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands;(5) Division of Haematology/Oncology, Department of Internal Medicine, University Hospital Maastricht, P.O. Box 30.001, 9700 RB Groningen, The Netherlands;(6) Department of Internal Medicine, University Hospital Utrecht, The Netherlands;(7) Department of Medical Oncology, Daniël den Hoed Kliniek, Rotterdam, The Netherlands;(8) Dutch Working Party on ABMT in Solid Tumors, The Netherlands |
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Abstract: | SummaryBackground This trial studied the disease-free survival after high-dose chemotherapy in patients in complete remission of metastatic breast cancer.Patients and methods Thirty women, mean age 42.2 years (range 33–55) with metastatic breast cancer, received high-dose chemotherapy in a phase II study. Patients were eligible if they were 55 years of age, had achieved complete remission within 6 months of the initiation of chemotherapy, and had a WHO performance scale of 0 or 1. The high-dose regimen consisted of melphalan 180 mg/m2 and mitoxantrone 60 mg/m2 both divided over 3 days. On day 7 bone marrow and/or peripheral stem cells were infused. After bone marrow recovery, external beam radiation was administered to sites of previous metastatic disease in 15 patients.Results Apart from leuko- and thrombocytopenia, mucositis was the major side effect. One patient died during the bone marrow transplant period due to an aspergillus infection. The median follow-up since highdose chemotherapy is 25 months (range 13 to 56 months). The median disease-free survival since high-dose chemotherapy is 27 months and the disease free survival is still 43% with an overall survival of 53% at 3 years. In two patients tumor relapse occurred only in the brain; in one patient the only relapse sign was a meningeal carcinosis. At the moment 17 patients are disease-free (13+–56+) months after high-dose chemotherapy.Conclusion Until now this high-dose regimen in selected patients with complete remission after induction chemotherapy for metastatic breast cancer has a promising disease free survival. |
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Keywords: | high-dose chemotherapy metastatic breast cancer |
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