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| 应激对雄性小鼠垂体-性腺功能的影响 | |
| 引用本文： | 周峰,郑琦,王亮,朱清.应激对雄性小鼠垂体-性腺功能的影响[J].南通医学院学报,2009,29(1). |
| 作者姓名： | 周峰 郑琦 王亮 朱清 |
| 作者单位： | 1. 江苏省射阳县人民医院药剂科,射阳,224300 2. 南通市中医院 3. 江苏天士力帝益药业有限公司 4. 南通大学医学院药学教研室 |
| 摘 要： | 目的:观察应激对雄性小鼠垂体一性腺功能的影响,建立应激性性机能下降动物模型.方法:利用电刺激方法使成熟雄性小鼠处于重复应激状态,然后观察雄鼠捕捉雌性小鼠的性行为活动,并用放射免疫方法测定血清中睾酮和促黄体生成素的水平.结果:重复电刺激应激后,雄性小鼠捕捉雌性小鼠的行为明显减少,表现为跨骑潜伏期延长,舔舐与跨骑次数减少(P<0.01).而且血清睾酮与促黄体生成素水平均下降(P<0.05,19<0.01).结论:重复电刺激应激可作为应激性性功能下降动物模型应用. |
| 关 键 词： | 垂体-性腺轴 应激 电刺激 性功能 睾酮 促黄体生成素 |
The effect of stress on function of hypophysial-gonadal axis in mature male mice |
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| ZHOU Feng,ZHENG Qi,WANG Liang,et al.The effect of stress on function of hypophysial-gonadal axis in mature male mice[J].ACTA Academiae Medicinae Nantong,2009,29(1). | |
| Authors: | ZHOU Feng ZHENG Qi WANG Liang |
| Institution: | 1ZHOU Feng,2ZHENG Qi,3WANG Liang,et al |
| Abstract: | Objective:To observe the effect of stress on function of hypophysial -gonadal axis in mature male mice,and establish the model of declined sexual function induced by stress. Methods: Mature male mouse was dealted with eletrical stimulation to make it in stress,then the sexual behaviour of male mice capturing female mice was observed and the testosterone and luteinizing hormone (LH) in mouse serum were determined by radioimmunoassay kit. Results: After repeated electrical stimulation of stress,male mouse act... |
| Keywords: | Hypophysial-gonadal axis Stress Electrical stimulation Sexual function Testosterone Luteinizing hormone |
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