miR-122在肝脏疾病调控中的作用研究进展

miRNA-122是MicroRNAs家族的一员,其在肝脏中高度特异性表达,参与肝脏的发育分化、基因表达调控和功能代谢,并与丙型肝炎病毒感染与肝癌的发生发展等密切相关。本文重点介绍miRNA-122在肝脏疾病调控中的作用研究进展。

Implication of model of end-stage liver disease in assessment of short and middle terms prognosis in patients with decompensated liver cirrhosis

Objective To investigate the implication of the model of end-stage liver disease（MELD）in assessment of short and middle term prognosis in patients with decompensated liver cirrhosis.Method 167 patients with decompensated liver cirrhosis admitted to our hospital were studied and followed up at least for one year.MELD and Child-Turcotte-Pugh （CTP）score were calculated at presentation.The receiver operation characteristic curves（ROC）and the area under ROC were used to determine the ability of predicting three,six and twelve month mortality.Result There were 23,42 and 66 dead cases at month 3,6 and 12,respectively;the MELD and CTP scores in dead were much higher than in survivals （P0.001）;the higher the MELD score,the higher risk the dead.Conclusion Both MELD and CTP scores can accurately predict the short and middle term prognosis of patients with decompensated liver cirrhosis.