| 缺氧缺血性脑病患儿脑脊液中IL-18的检测及意义 |
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| 引用本文： | 王品品,胡玉莲,张家洁,于凤琴. 缺氧缺血性脑病患儿脑脊液中IL-18的检测及意义[J]. 中国现代医生, 2008, 46(9): 48-49 |
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| 作者姓名： | 王品品 胡玉莲 张家洁 于凤琴 |
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| 作者单位： | 郑州市妇幼保健院新生儿科,郑州,450012 |
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| 摘 要： | 目的研究HIE患儿脑脊液中IL-18的变化及其临床意义。方法采用双抗体夹心酶联免疫吸附法，对42例足月缺氧缺血性脑病患儿脑脊液中IL-18进行检测，其中轻度HIE23例，中重度HIE19例。同时检测38例正常足月新生儿脑脊液中IL-18的水平。结果缺氧缺血性脑病患儿脑脊液中IL-18的水平比正常新生儿脑脊液中IL-18的水平显著增高。结论脑脊液中IL-18的水平可能参与缺氧缺血性脑病的发病过程，为IL-18BP治疗HIE提供理论基础。
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| 关 键 词： | 缺氧缺血性脑病 IL-18 新生儿 ELISA |
| 文章编号： | 1673-9701(2008)09-48-02 |
| 修稿时间： | 2008-01-20 |
Significances of IL-18 Change in Hypoxic-ischemic Encephalopathy Newborns |
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| WANG Pinpin,HU Yulian,ZHANG Jiajie,YU Fengqin. Significances of IL-18 Change in Hypoxic-ischemic Encephalopathy Newborns[J]. , 2008, 46(9): 48-49 |
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| Authors: | WANG Pinpin HU Yulian ZHANG Jiajie YU Fengqin |
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| Affiliation: | (Demprtment of Pediatrics, Maternal and Child Care Service Center, Zhengzhou 450012) |
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| Abstract: | Objective To study the change of IL-18 in cerebrospinal liquid in hypoxic-ischemic encephalopathy newborn infants. Methods Sixty-three term newborns suffered from HIE were divided into two groups, mild HIE group（n=23）, moderate-severe HIE group （n=19）. Thirty-eight non-HIE term newborn infants worked as control group. Level of IL-18 was examined by ELISA. Results Level of IL-18 in mild HIE group was lower than that in moderate-severe HIE group on the 3^rd and the 7^th day. Conclusion IL-18 is a damage pro motion factor of brain cell in HIE. Monitoring the trend of IL-18 in early life is helpful to judge the state of disease and estimate the prognosis. |
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| Keywords: | Hypoxic-ischemic encephalopathy IL-18 Neonate ELISA |
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