血清及腹腔液CA125测定对子宫腺肌病的诊断价值

目的探讨血清及腹腔液CA125测定对子宫腺肌病的诊断价值.方法采用免疫化学发光法测定28例子宫腺肌病和25例子宫肌瘤患者血清及腹腔液(110稀释)CA125水平.结果子宫腺肌病患者血清CA125水平高于子宫肌瘤患者,差异有显著性(P＜0.01).两组间腹腔液CA125水平差异无显著性(P=0.18).腹腔液CA125水平明显高于血清CA125水平(P＜0.01),但二者无明显相关性(P＞0.50).腺肌病患者血清CA125水平受子宫大小、大体病理类型、使用性激素等因素影响.结论如用于子宫腺肌病的辅助诊断,血清CA125测定较腹腔液CA125测定敏感.腹腔液中CA125的主要来源可能为腹膜上皮细胞.

Evaluation of sera and peritoneal fluid CA125 levels in patients with adenomyosis of uterus

Objective To investigate the values of sera and peritoneal fluid CA125 assays in the diagnosis of adenomyo-sis. Methods Twenty-eight patients with adenomyosis and twenty-five with leiomyoma of uterus with diagnosis confirmed by pathology were studied.The blood samples were taken on the operation day just before anesthesia, while peritoneal fluid samples were obtained before exploration.CA125 levels were determined by chemiluminescent enzyme immunometric assay.All peritoneal fluid samples were diluted 10 times before assay.Results The median serum CA125 level of adenomyosis was significantly higher than that of leiomyoma ( P < 0.01) . Peritoneal fluid CA125 levels were significantly higher than serum levels ( P < 0.01) , but showed no significant difference between adenomyosis and leiomyoma patients (P = 0.18) .There was no significant correlation between peritoneal CA125 and sera CA125 (P > 0.50) .Sera CA125 levels were affected by several factors, such as the size of uterus , pathology type , and hormone therapy. Conclusions Sera CA125 was more sensitive than peritoneal fluid CA125 in the diagnosis of adenomyosis. The main source of peritoneal fluid CA125 was probably from peritoneum epithelial cells.