| 屏氧酶-1基因多态性与腔隙性脑梗死 |
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| 引用本文： | 陈卫蓉,肖志杰,赵斯卿,赵水平,张海南,王春喻. 屏氧酶-1基因多态性与腔隙性脑梗死[J]. 卒中与神经疾病, 2006, 13(2): 75-78 |
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| 作者姓名： | 陈卫蓉 肖志杰 赵斯卿 赵水平 张海南 王春喻 |
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| 作者单位： | 1. 410011,长沙市妇幼保健医院
2. 中南大学湘雅二医院 |
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| 摘 要： | 目的探讨屏氧酶-1(PON-1)基因192位G ln-Arg(Q/R192)多态性与腔隙性脑梗死的关系。方法采用聚合酶链式反应(PCR)限-制性片段长度多态性方法测定109例腔隙性脑梗死患者(腔隙性脑梗死组)和339名健康普查者(对照组)PON-1Q/R192基因多态性,并进行基因型的比较。结果在腔隙性脑梗死人群中PON-1Q/R192 3种基因型频率分别为QQ 15.6%、QR 52.3%、RR 32.1%。PON-1Q/R192基因型和等位基因频率分布在腔隙性脑梗死组与对照组之间无显著性差异(P>0.05);各基因型之间血脂水平也无显著性差异(P>0.05)。结论腔隙性脑梗死和非腔隙性脑梗死的PON-1Q/R192的基因多态性无明显差异。
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| 关 键 词： | 屏氧酶-1 基因多态性 腔隙性脑梗死 |
| 文章编号： | 1007-0478（2006）02-0075-04 |
| 收稿时间： | 2005-09-26 |
| 修稿时间： | 2005-09-26 |
The relationship between the gene polymorphism in paranoxonasel and lacunar infarction |
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| Chen Weirong, Xiao Zhijie , Zhao Siqing ,et al.. The relationship between the gene polymorphism in paranoxonasel and lacunar infarction[J]. Stroke and Nervous Diseases, 2006, 13(2): 75-78 |
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| Authors: | Chen Weirong Xiao Zhijie Zhao Siqing et al. |
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| Affiliation: | Department of Neurology, Xiangya Second Hospital of Central South University ,Changsha 410011 |
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| Abstract: | Objective To investigate the correlation between the paraoxonase Gln-Arg 192 polymorphism(PON-1Q/R192) and lacunar infarction.Methods This was a case-control study,which enrolled 109 cases with lacunar infarction and 339 controls without CHD and CVD.Polymerase chain reaction-restricted fragments length polymorphism was used to determine PON-1Q/R192.Results The PON-1Q/R192 genotype distribution in cases of lacunar infarction was QQ(15.6%),QR(52.3%) and RR(32.1%),respectively.There was no significant difference in PON-1Q/R192 allele and genotype distribution between the lacunar infarction group and the control group.No significant association between Q/R192 genotype and the profile of blood lipids was detected.Conclusions These results suggest that the PON-1Q/R192 gene polymorphism is not associated with lacunar infarction. |
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| Keywords: | Paraoxonase Polymorphism Lacunar infarction |
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