Proton magnetic resonance spectroscopy reflects cellular proliferative activity in astrocytomas |
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Authors: | T Tamiya K Kinoshita Y Ono K Matsumoto T Furuta T Ohmoto |
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Institution: | (1) Department of Neurological Surgery, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan e-mail: ttamiya@med.okayama-u.ac.jp, Tel.: + 81-86-2 35 73 36, Fax: + 81-86-2 27 01 91, JP |
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Abstract: | We examined whether proton magnetic resonance spectroscopy (MRS) could provide accurate information on histological grade
and cell proliferation in astrocytomas. We studied 23 patients with astrocytomas: five grade II, 10 grade III and eight with
grade IV (glioblastoma multiforme). We performed proton MRS and determined the Ki-67 labeling index (LI), a tumour proliferation
marker, in the same areas of the astrocytomas, and examined the statistical relationship between proton MRS and Ki-67 LI.
The N-acetylaspartate (NAA)/creatine-phosphocreatine (Cr) and NAA/choline (Cho)-containing compound ratios were always significantly
lower and the Cho/Cr ratios significantly higher than those for normal brain. The Cho/Cr ratio correlated positively and the
NAA/Cho ratio inversely with Ki-67 LI. These findings suggest that the Cho signal in proton MRS reflects cellular proliferation.
In Kaplan-Meier survival analysis, there was no significant difference between high (> 2.0, 14 cases) and low (< 2.0, 9 cases)
Cho/cr ratio groups.
Received: 24 December 1998/Accepted: 11 August 1999 |
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Keywords: | Astrocytoma Magnetic resonance spectroscopy Ki-67 |
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