PPI引起艰难梭状芽孢杆菌性腹泻的危险因素

目的:评价治疗酸相关性疾病患者的质子泵抑制剂是引起艰难梭状芽孢杆菌性腹泻的另类危险因素。方法:查阅近期文献进行评价和分析。结果:队列研究表明艰难梭状芽孢杆菌性腹泻发生于约6.8%用过抗生素的住院患者,多自变量因素分析表明艰难梭状芽孢菌性腹泻与质子泵抑制剂的应用明显相关。结论:抗生素破坏了正常肠道菌群,公认是引起艰难梭状芽孢杆菌性腹泻的危险因素,而胃酸度降低一直被认为是其危险因素,质子泵抑制剂因为其强力的抑酸作用,可能是致艰难梭状芽孢杆菌性腹泻的独立危险因素。

Proton Pump Inhibitors as a Risk Factor for Clostridium Difficile - Associated Diarrhea

OBJECTIVE:To assess the possibility that proton pump inhibitors treating the patients with acid-associated diseases had other risk factors for C. difficile infection. METHODS :To review recent literatures for an analysis. RESULTS: Cohort study showed that C. difficile diarrhea occurred in about 6.8% of the inpatients who used antibiotics. A multivariate analysis indicated that C. difficile diarrhea was significantly associated with the use of proton pump inhibitors. CONCLUSION: Disruption of the normal intestinal flora is generally considered to be the risk factor for inducing clostridium difficile-associated diarrhea. Reduced gastric acidity has been suggested as a risk factor. Proton pump inhibitors, because of their strong acid-inhibiting effect, may be an independent risk factor for this problem.