| 自然流产与绒毛中维甲酸X受体α基因突变关系的研究 |
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| 引用本文： | 张羽,林其德,王育,赵爱民,汪希鹏,黄立东.自然流产与绒毛中维甲酸X受体α基因突变关系的研究[J].现代妇产科进展,2004,13(2):122-124. |
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| 作者姓名： | 张羽 林其德 王育 赵爱民 汪希鹏 黄立东 |
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| 作者单位： | 1. 上海第二医科大学附属仁济医院妇产科,上海,200001
2. 上海第二医科大学神经生物学教研室 |
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| 基金项目： | 国家自然科学基金资助项目 (39870 6 6 6 ) |
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| 摘 要： | 目的 :探讨人类自然流产与绒毛中维甲酸X受体α(RXRα)基因突变的关系。方法 :用PCR SSCP 银染法和DNA测序法检测了自然流产 5 0例和正常早孕要求人工流产4 0例的胚胎绒毛组织中RXRα基因的外显子 2～ 10的突变。结果 :4 9例患者和正常对照组绒毛组织中RXRα基因的各个外显子在PCR SSCP 银染检测中均未显示异常。 1例患者SSCP 银染中显示异常的第 9外显子序列经DNA测序后未发现突变。结论 :目前尚不能认为人类自然流产与绒毛中RXRα基因突变有关
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| 关 键 词： | 流产 自然 绒毛膜绒毛 受体 维甲酸 突变 |
| 文章编号： | 1004-7379(2004)02-0122-03 |
| 修稿时间： | 2003年11月2日 |
Study of the relation between spontaneous abortion and mutations in retinoic X receptor α gene in chorionic villi |
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| Zhang Yu,Lin Qide,Wang Yu,et al..Study of the relation between spontaneous abortion and mutations in retinoic X receptor α gene in chorionic villi[J].Current Advances In Obstetrics and Gynecology,2004,13(2):122-124. |
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| Authors: | Zhang Yu Lin Qide Wang Yu |
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| Institution: | Zhang Yu,Lin Qide,Wang Yu,et al.Department of Obstetrics and Gynecology,Shanghai Renji Hospital,Shanghai Second Medical University,Shanghai 200001 |
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| Abstract: | Objective:To investigate the relation between human spontaneous abortion and mutations in retinoic X receptor α gene in chorionic villi. Method:50 spontaneous abortion patients and 40 normal early pregnant women requesting pregnancy termination were determined for mutations in the exon 2～10 of RXRα gene in their chorionic villi by PCR-SSCP-silver stain and DNA sequencing.Results:All the subjects except for one patient were found to be normal in the exons of RXRα gene in their chorionic villi by PCR-SSCP-silver stain determinations.After DNA sequencing,no mutations were found in this patient of the exon 9 sequences which had showed abnormal in SSCP-silver stain.Conclusion:No relation has been found between human spontaneous abortion and mutations in RXRα gene in chorionic villi. |
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| Keywords: | Abortion spontaneous Chorionic villi Receptors retinoic acid Mutation |
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