Tonsillectomy and risk of Parkinson's disease: A danish nationwide population‐based cohort study |
| |
| Authors: | Elisabeth Svensson PhD Victor W. Henderson MD Szimonetta Szépligeti MSc Morten Gersel Stokholm MD Tejs Ehlers Klug MD DMSc Henrik Toft Sørensen MD DMSc Per Borghammer MD DMSc |
| |
| Affiliation: | 1. Department of Clinical Epidemiology,Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark;2. The Danish Clinical Registries, Denmark;3. Department of Health Research & Policy, Stanford University, Stanford, California, USA;4. Department of Neurology & Neurological Sciences, Stanford University, Stanford, California, USA;5. Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark;6. Department of Otorhinolaryngology, Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark |
| |
| Abstract: | Background : We hypothesized that tonsillectomy modifies the risk of PD. Objectives: To test the hypothesis in a nationwide population‐based cohort study. Methods: We used Danish medical registries to construct a cohort of all patients in Denmark with an operation code of tonsillectomy 1980‐2010 (n = 195,169) and a matched age and sex general population comparison cohort (n = 975,845). Patients were followed until PD diagnosis, death, censoring, or end of follow‐up 30 November 2013. Using Cox regression, we computed hazard ratios for PD and corresponding 95% confidence intervals, adjusting for age and sex by study design, and potential confounders. Results: We identified 100 and 568 patients diagnosed with PD among the tonsillectomy and general population comparison cohort, respectively, finding similar risks of PD (adjusted hazard ratio = 0.95 [95% confidence interval: 0.76‐1.19]; for > 20 years' follow‐up (adjusted hazard ratio = 0.96 [95% confidence interval: 0.64‐1.41]). Conclusion: Tonsillectomy is not associated with risk of PD, especially early‐onset PD. © 2017 International Parkinson and Movement Disorder Society |
| |
| Keywords: | tonsils tonsillectomy prion Parkinson's disease risk factor epidemiology cohort study |
|
|
