| 支气管哮喘遗传流行病学的初步分析 |
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| 引用本文： | 金永堂,陈常中.支气管哮喘遗传流行病学的初步分析[J].卫生研究,1998,27(1):29-31. |
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| 作者姓名： | 金永堂 陈常中 |
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| 作者单位： | 安徽医科大学环境卫生学教研室 |
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| 基金项目： | 美国哈佛大学公共卫生学院资助 |
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| 摘 要： | 利用遗传流行病学的理论与方法，对６４１个核心家系完整资料分析的结果表明，父母患哮喘是其子女患哮喘的重要因素，患哮喘的危险性比父母均不患哮喘家系的子女增加４．０～８．０倍，这种差别具有高度显著性意义。父母对子女患哮喘危险性的影响呈现显著的线性趋势（Ｐ＜０．０１）。显示了哮喘的发病具有家族聚集性。同时分析了父母患哮喘的儿子与女儿患哮喘危险性，没有发现两者间的显著性差别（Ｐ＞０．０５）。本研究没有发现父母的气道反应性与其子女的气道反应性有显著相关性。本文初步研究结果提示哮喘发病过程中，遗传因素起着重要的作用。
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| 关 键 词： | 哮喘 遗传学 流行病学 |
Genetic Epidemiological Study of Asthma in General |
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| Y Jin,C Chen,Y Xu,Z A Fang.Genetic Epidemiological Study of Asthma in General[J].Journal of Hygiene Research,1998,27(1):29-31. |
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| Authors: | Y Jin C Chen Y Xu Z A Fang |
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| Institution: | Department of Environmental Health, Anhui Medical University, Hefei, China. |
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| Abstract: | With theory and method of genetic epidemiology, data of 641 nuclear families on asthma were analysed, and the results showed that the history of parents asthma was one of risk factors about offsprings asthma, and the risk was 4.0-8.0 times higher (P < 0.01), compared with the one of offsprings of parents with no asthma. The effect of parents with asthma on the risk of sons was the same as one of daugters. The result declared that the airway responsiveness of parents did not relate to the one of offsprings. The results suggest that the genetic factors play an important role in the asthma. |
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| Keywords: | asthma genetics epidemiology |
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