硒和镉对大鼠肝细胞DNA损伤的联合作用

应用单细胞凝胶电泳研究硒和镉对大鼠肝细胞ＤＮＡ损伤的联合作用。结果表明，硒和镉在浓度超过８．７５μｍｏｌ／Ｌ时，均可引起细胞ＤＮＡ损伤，硒引起的损伤程度较镉轻。在８．７５、１７．５μｍｏｌ／Ｌ浓度条件下，当硒和镉联合作用时所致ＤＮＡ损伤程度明显低于相同剂量下硒、镉的单独作用，而在３５μｍｏｌ／Ｌ浓度条件下，硒镉联合作用所致ＤＮＡ损伤与硒、镉单独作用时比较，差异无显著性。本研究结果提示，在一定剂量时，硒和镉致大鼠肝细胞ＤＮＡ损伤存在拮抗作用。

Study on the joint action of selenium and cadmium on DNA damage of rat liver cells]

The effect of joint action of selenium and cadmium on DNA damage in rat liver cells was investigated with single cell gel electrophoresis. The results show that both selenium and cadmium can induce DNA damage at the concentration of 8.75 mumol/L, 17.5 mumol/L and 35 mumol/L. The degree of DNA damage induced by cadmium is more serious than by selenium. When selenium and cadmium act jointly, they can antagonize each other on DNA damage at the concentration of 8.75 mumol/L and 17.5 mumol/L, but not at the concentration of 35 mumol/L. There is an antagonism between selenium and cadmium on DNA damage in rat liver cells at certain concentrations.