新生儿脐带血乙肝标志物模式分析与临床价值

目的检测乙肝表面抗原（HBsAg）阳性产妇脐带血标本乙肝标志物,评价其临床价值。方法将HBsAg阳性产妇分为双阳性（HBsAg、HBeAg阳性）组和单阳性（HBsAg阳性、HBeAg阴性）组,在其分娩后留取新生儿脐带血进行乙肝标志物的检测。结果新生儿脐带血HBsAg阳性48例,宫内感染率3.46%,双阳性孕妇组新生儿宫内感染率6.78%,单阳性孕妇组新生儿宫内感染率2.09%,两组新生儿宫内感染率有显著差异（P〈0.01）。结论 HBsAg、HBeAg双阳性产妇更易发生宫内感染,双阳性育龄妇女,应积极治疗,待HBeAg转阴后再妊娠,以降低HBV母婴传播的机率。

Clinical Value and Pattern Analysis of Detection of Hepatitis B Virus Markers in Cord Blood of Newborn

Objective To detect the HBV markers in maternal woman with HBsAg positive and evaluate its clinical value.Method To divide HBsAg-positive woman into double-positive（HBsAg,HBeAg-positive） group and single-positive（HBsAg positive,HbeAg negative） group,to detect the HBV markers in cord blood of newborn after parturition.Result The HBsAg positive in umbilical cord blood was 48 and intrauterine infection rate was 3.46%.The intrauterine infection rate in double-positive group was 6.78%,and single-positive group was 2.09%.There was significant difference in the two groups（P 0.01）.Conclusion Both HBsAg and HBeAg positive women are more likely to have intrauterine infection.In order to reduce the probability of HBV transmission,the double-positive women in childbearing age should be treated actively until HBeAg becomes negative to prepare for pregnancy.