Compact platelet-rich fibrin scaffold to improve healing of patellar tendon defects and for medial collateral ligament reconstruction |
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| Authors: | Daigo Matsunaga Shaw Akizuki Tsutomu Takizawa Shinichiro Omae Hiroyuki Kato |
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| Affiliation: | 1. Department of Orthopedic Surgery, Nagano Matsushiro General Hospital, 183 Matsushiro, Nagano 381-1231 Japan;2. Research and Development Division, Omae Sansuukokugo School, Nakano, Nagano, Japan;3. Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan;1. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia;2. Brisbane Orthopaedic Specialist Services, Holy Spirit Northside Hospital, Brisbane, Queensland, Australia;1. Department of Orthopaedics, Takagi Hospital Oume Knee Surgery Center, Tokyo, Japan;2. Ishii Orthopaedic and Rehabilitation Clinic, Saitama, Japan;3. Institute of Rheumatology, Tokyo Women''s Medical University, Tokyo, Japan;4. Department of Mechanical & Aerospace Engineering, University of Florida, Gainesville, FL, USA;5. Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL, USA |
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| Abstract: | BackgroundPlatelets are one of the most biocompatible and cost-effective sources of growth factors. Attention is being paid to autologous platelets and platelet-rich plasma. We developed a novel compact platelet-rich fibrin scaffold (CPFS) that was produced from blood and calcium gluconate only. The objective of this study was to investigate the potential of CPFS as a provisional scaffold in two rabbit models.MethodsIn the first rabbit model, the central half of the patellar tendon was resected bilaterally. Allogenic CPFS was attached to the defect in the right knee, while the left knee was untreated. In the other model, the medial collateral ligament was removed bilaterally. The ligament of the right knee was reconstructed with allogenic CPFS, whereas the left knee was untreated.ResultsAfter 12 weeks, the ultimate failure load and stiffness were higher for the right patellar tendon than for the left patellar tendon in the former model. It was found that CPFS promoted ligament repair tissue in contrast with that on the untreated side in the latter model. The ultimate failure load of the CPFS repair tissue at 20 weeks was 78% of that in healthy controls of the same age.ConclusionsCPFS enhanced the healing of tendons and ligaments.Clinical relevanceCPFS has the potential to accelerate healing of tendons and ligaments as a provisional bioscaffold or a material for graft augmentation. |
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