富血小板血浆联合负压封闭引流技术治疗慢性难愈性创面的研究

目的 探究富血小板血浆(platelet rich plasma,PRP)联合负压封闭引流技术(vacuum sealing drainage,VSD)治疗慢性难愈性创面的临床效果.方法 选取2019年3月-2020年6月在蚌埠医学院第一附属医院整形烧伤科收治且符合选择标准的40例慢性难愈性创面患者,按照随机数字表法分...

Platelet-rich plasma combined with vacuum-sealing drainage in treating chronic refractory wounds

Objective To investigate the clinical effect of platelet-rich plasma(PRP) combined with vacuum-sealing drainage(VSD) in treating chronic refractory wounds. Methods From March 2019 to June 2020, 40 patients with chronic refractory wounds admitted in the Department of Plastic and Burn, the First Affiliated Hospital of Bengbu Medical College, were selected and randomly divided into two groups, namely, control(only using VSD to cover the wound) and observation groups using PRP to inject the base and margin of wounds and using VSD to cover the wounds, 20 cases in each group. The length of hospital stay, effective rate of treatment, postoperative wound pain score(using visual analogue scale), and histomorphological characteristics of wound under HE staining were compared between the two groups. Results In the control group, 2 cases were ineffective, 10 cases were effective, and 8 cases were markedly effective;in the observation group, 0 cases were ineffective, 0 cases were effective, and 20 cases were markedly effective. Compared with the control group, the average length of stay in the observation group was significantly shorter [(27.10±8.63) d vs.(20.10±3.60) d, P<0.01], and the effective rate was significantly increased(40.00% vs. 100.00%,P<0.01). Results of HE staining showed that the inflammatory reaction of the control group was obvious, and the number of new granulation tissue and blood vessels was less in the control group, whereas the inflammatory reaction in the observation group was lighter, the number of new granulation tissue and blood vessels was higher, and the re-epithelialisation rate was higher in the observation group. Conclusion For patients with chronic refractory wounds, compared with the traditional PRP gel technology, PRP injection combined with VSD treatment can stimulate angiogenesis, improve the local blood circulation, accelerate the recovery of patients, relieve postoperative pain, shorten the length of stay, reduce the cost of treatment, and achieve good therapeutic effect.