Suppressive Effect of Flavonoids from Korean Citrus aurantium L. on the Expression of Inflammatory Mediators in L6 Skeletal Muscle Cells |
| |
| Authors: | Jin‐A. Kim Hyeon‐Soo Park Sang‐Rim Kang Kwang‐Il Park Do‐Hoon Lee ArulKumar Nagappan Sung‐Chul Shin Won‐Sup Lee Eun‐Hee Kim Gon‐Sup Kim |
| |
| Affiliation: | 1. Korea National Animal Research Resource Center, Korea National Animal Bio‐Resource Bank, Gyeongsang National University, , Jinju, 660‐701 Republic of Korea;2. Research Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, , Jinju, 660‐701 Republic of Korea;3. Department of Biological Engineering, Kyongi University, , suwon, 443‐760 Republic of Korea;4. Department of Chemistry and Research Institute of Life Science, Gyeongsang National University, , Jinju, 660‐701 Republic of Korea;5. Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Gyeongnam Regional Cancer Center, Gyeongsang National University Hospital, , Jinju, 660‐702 Republic of Korea;6. Department of Nursing Science, International University of Korea, , 660‐759 Republic of Korea |
| |
| Abstract: | Citrus fruits (Citrus aurantium L.) have long been used as a traditional herbal medicine. The benefits of the flavonoids found in Citrus aurantium L. include anti‐inflammation, anti‐cancer, anti‐viral and anti‐bacterial activities, and enhancement of the immune response. The study investigated the effect of the flavonoids isolated from Citrus aurantium L. native to Korea on the production of pro‐inflammatory mediators by blocking signal transduction mediated by nuclear factor‐kappa B (NF‐κB) and mitogen‐activated protein kinases (MAPKs) in lipopolysaccharide (LPS)‐induced L6 skeletal muscle cells. The flavonoids decreased the production of inducible nitric oxide synthase, cyclooxygenase‐2, interleukin‐6 and tumor necrosis factor‐alpha by suppressing NF‐κB and MAPKs signal pathways in LPS‐induced L6 skeletal muscle cells. These findings suggest that the flavonoids isolated from Korea Citrus aurantium L. might have anti‐inflammatory effects that regulate the expression of inflammatory mediators in L6 skeletal muscle cells. Copyright © 2012 John Wiley & Sons, Ltd. |
| |
| Keywords: | flavonoids Korea Citrus aurantium L L6 skeletal muscle cell lipopolysaccharide (LPS) nuclear factor‐kappa B (NF‐κ B) mitogen‐activated protein kinases (MAPKs) |
|
|
