Postbypass Treatment |
| |
| Authors: | Harold Feinberg Sidney Levitsky |
| |
| Institution: | From the Departments of Pharmacology and Surgery, School of Basic Medical Science and Abraham Lincoln School of Medicine of the University of Illinois College of Medicine, Chicago, Ill. |
| |
| Abstract: | Ischemia induced by cross-clamping the aorta during open-heart operations initiates progressive metabolic derangement. If the duration of ischemia is short, these derangements are easily reversed by restoring the flow of blood containing oxygen and substrate. If ischemia is prolonged, treatment designed to ameliorate ischemic damage may be necessary. Three problems are discussed: (1) loss of adenine nucleotides, particularly adenosine triphosphate, (2) impairment of calcium sequestration, and (3) formation of microemboli in coronary vessels. The rationale for postbypass treatment is presented. |
| |
| Keywords: | Address reprint requests to Dr Levitsky Department of Surgery Abraham Lincoln School of Medicine of the University of Illinois College of Medicine P O Box 6998 Chicago Ill 60680 |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
