高敏C反应蛋白、B型钠尿肽与急性心肌梗死患者心功能关系的临床研究

目的探讨高敏C反应蛋白（hs—CRP）、B型钠尿肽（BNP）两个指标在急性心肌梗死（AMI）发作期间改变与心功能的相互关系，以探讨两者与AMI预后的相关性。方法测定非急性心肌梗死患者81例（对照组）和AMI患者86例的血清CRP浓度，同时以彩色多普勒检测并计算左室射血分数（INEF）、左室后壁收缩期增厚率（△T％）和血液检查BNP。结果AMⅡ组、Ⅱ组、Ⅲ组和Ⅳ组中血清hs-CRP和BNP水平明显高于对照组，并随心功能Killip分级的严重程度增加而升高，血清hs—CRP与BNP水平和心功能Killip分级呈IE相关（r=0．38、r=0．51，均P〈0．01）。结论AMI患者血清hs—CRP和BNP水平明显升高，与心功能Killip分级呈正相关。

Correlation of hs-CRP and BNP with cardiac function in patients with acute myocardial infarction

Objective To examine the correlation of the high sensitive-CRP （hs-CRP） levels and BNP with Cardiac function during the onset of acute myocardial infarction （AMI）. Methods The serum levels of hs-CRP, BNP were detected in 81 with non-AMl and 86 patients with AMI. Left ventricular ejection fraction （LVEF） and left ventilator posterior wall thickness growing rate at systole（ △T% ） were measured by echocardiography. Results Compared with control group, AMI patients had high serum levels of hs-CRP. The higher of Killip class, the higher the levels of hs-CRP and BNP. The levels of hs-CRP and BNP were positive correlation with Killip class （ r = 0.38, r = 0.51, P 〈0.01）. Conclusion The levels of serum hs-CRP and BNP significantly increased in the AMI patients. The levels of hs-CRP and BNP are positive correlation with Killip class.