血必净注射液治疗急性呼吸窘迫综合征的临床疗效及对肿瘤死因子和白细胞介素-8水平的影响研究

目的观察血必净注射液对治疗急性呼吸窘迫综合征(ARDS)的临床疗效及对患者肿瘤坏死因子(TNF)及白细胞介素-8(IL-8)水平的影响。方法将70例ARDS患者随机为2组,均予常规治疗,治疗组35例加血必净注射液治疗,对照组35例加地塞米松磷酸钠注射液治疗。2组均连续治疗7 d。统计临床疗效,检测2组入院后第1、3、5、7 d TNF及IL-8水平变化情况。结果治疗组总有效率97.14%,对照组总有效率82.85%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。2组入院后第3、5、7 d TNF及IL-8水平与本组入院后第1 d比较均明显下降(P<0.05),且2组组间同期比较差异均有统计学意义(P<0.05),治疗组低于对照组。结论血必净注射液能显著降低ARDS患者TNF及IL-8水平,阻断肺损伤演变进程,促进肺组织修复和肺功能恢复。

Investigation of Xuebijing injection on the treatment of acute respiratory distress syndrome

Objective To investigate the clinical significance and effect of Xuebijing injection on tumor necrosis factor（TNF） and interleukin-8（IL-8） levels in patients with acute respiratory distress syndrome（ARDS）.Methods 70 cases of ARDS were randomly divided into two groups.Patients in two groups were treated by routine therapy.Patients in treatment group（n=35） were additionally treated by Xuebijing injection.Patients in control group（n=35） were additionally treated by Dexamethasone sodium phosphate injection.The two groups were treated for 7 consecutive days.Clinical efficacy was analyzed.The levels changes of TNF and IL-8 in two groups were observed 1,3,5,7 days after admission.Results The total effective rate in treatment group and control group was 97.14% and 82.85%,respectively.There was statistically significant between two groups in total effective rate（P0.05）.The levels of TNF and IL-8 3,5,7 days after admission were obviously decreased as compared with these 1 day after admission in two groups（P0.05）.There was statistically significant between two groups in the levels of TNF and IL-8 3,5,7 days after admission（P0.05）.The levels of TNF and IL-8 3,5,7 days after admission in treatment group were lower than those in control group.Conclusion Xuebijing injection can significantly reduce the TNF and IL-8 levels in patients with ARDS,blocking the lung injury process of evolution and promote lung tissue repair and lung function recovery.