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| 螺内酯对慢性心力衰竭患者心率变异性及左室重构的影响 | |
| 引用本文： | 魏梅,刘永升,刘会英,张慧敏,王乐,王心妹.螺内酯对慢性心力衰竭患者心率变异性及左室重构的影响[J].实用老年医学,2012,26(4):317-318,322. |
| 作者姓名： | 魏梅 刘永升 刘会英 张慧敏 王乐 王心妹 |
| 作者单位： | 1. 秦皇岛市第一医院心内二科,河北省秦皇岛市,066000 2. 秦皇岛市第一医院老年病一科,河北省秦皇岛市,066000 3. 乐亭县中医院外一科,河北省唐山市,063600 |
| 摘 要： | 目的探讨螺内酯对慢性心力衰竭患者心率变异性及左室重构的影响。方法选取86例慢性心力衰竭患者,随机分为常规治疗组和螺内酯组,测定治疗前及治疗3月后24h平均正常R-R间期标准差(SDNN)、24h连续5min节段平均正常R-R间期标准差(SDANN)及连续正常R-R间期差的均方根(rMSSD),采用超声诊断仪测定左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)的变化。结果螺内酯组患者的心率变异性指标SDNN、SDANN及rMSSD明显增加,左心重构指标LVEDD、LVESD明显下降,LVEF明显上升(P<0.05)。结论螺内酯能够有效改善慢性心力衰竭患者的心率变异性及改善左室重构。 |
| 关 键 词： | 螺内酯 心力衰竭 心率变异性 左室重构 |
Effects of spironolactone on the heart rate variability and ventricular remodeling in chronic congestive heart failure patients |
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| WEI Mei , LIU Yong-sheng , LIU Hui-ying , ZHANG Hui-min , WANG Le , WANG Xin-mei.Effects of spironolactone on the heart rate variability and ventricular remodeling in chronic congestive heart failure patients[J].Practical Geriatrics,2012,26(4):317-318,322. | |
| Authors: | WEI Mei LIU Yong-sheng LIU Hui-ying ZHANG Hui-min WANG Le WANG Xin-mei |
| Institution: | . Depaptment of Geriatrics, the First Hospital of Qinhuangdao, Qinhuangdao 066000, China; LIU Hui-ying. Department of Surgery, Leting County Hospital of Traditional Chinese Medicine, Tangshan 063600, China |
| Abstract: | Objective To observe the changes of heart rate variability(HRV), ventricular remodeling parameters after intervention with spironolactone. Methods Eighty-six patients with CHF were randomly assigned to conventional therapy group and spironolactone group,HRV and cardiac function parameters were measured before and 3 months after intervention. Results After 3 months of therapy, SDNN,SDANN,rMSSD and LVEF were all improved in spironolactone group,LVEDD,LVESD were reduced in spironolactone group (P<0.05). Conclusions Spironolactone can obviously improve HRV and ventricular remodeling in CHF patients. |
| Keywords: | spironolactone heart failure heart rate variability ventricular remodeling |
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