| HPLC法测定橘红化痰胶囊中吗啡的含量 |
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| 引用本文： | 张秀荣,江济霞,袁兆坤. HPLC法测定橘红化痰胶囊中吗啡的含量[J]. 现代中药研究与实践, 2009, 23(2): 39-41 |
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| 作者姓名： | 张秀荣 江济霞 袁兆坤 |
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| 作者单位： | 皖北药业股份有限公司,安徽,宿州,234000;安徽歙县中医院,安徽,歙县,245200;安徽圣鹰药业有限公司,安徽,合肥,230088 |
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| 摘 要： | 目的建立橘红化痰胶囊中吗啡的含量测定方法。方法采用HPLC法,ODS-C18色谱柱(4.6mm×200mm,5μm);以乙腈acetonitrile-0.01mol/L磷酸氢二钾溶液-0.005mol/L庚烷磺酸钠水溶液(18:42:40)为流动相movingphase;检测波长为220nm;进样量10μL。结果吗啡在0.04816-0.43344μg/mL范围内与其峰面积呈良好的线性关系(r=0.9998),加样回收率为98.63%(RSD为0.84%,n=6)。结论本方法具有操作简便、分离度、精密度、重复性好,回收率高、重现性好等特点,可以作为橘红化痰胶囊中吗啡的含量测定方法。
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| 关 键 词： | 橘红化痰胶囊 吗啡 含量测定 |
Determination of Morphine in Juhong Huatan Capsules by HPLC |
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| ZHANG Xiu-rong,JIANG Ji-xia,YUAN Zhao-kun. Determination of Morphine in Juhong Huatan Capsules by HPLC[J]. Research and Practice on Chinese Medicines, 2009, 23(2): 39-41 |
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| Authors: | ZHANG Xiu-rong JIANG Ji-xia YUAN Zhao-kun |
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| Abstract: | Objective To etablish a method for determination of morphine in Juhong Huatan capsules.Methods ODS-C18 column(4.6 mm×200 mm,5 μm) was used,the mobile phase consisted of acetonitrile-0.01 mol/L dipotassium hydrogen phosphate solution-0.005mol/L sodium heptanesulfonate solution (18:42:40), the detectin wavelength was 220 mm. Results The linear range was 0.048 1 6-0.433 44 μg/mL(r=0.999 8), the average recovery was 98.63 % (n=6).Conclusion The method is simple,and accuraet , and can be used for quality ontrol of Juhong Huatan capsules. |
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| Keywords: | Juhong Huatan capsules morphine content determination |
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