Can amino-functionalized carbon nanotubes carry functional nerve growth factor? |
| |
作者姓名: | Wen Chen Qing Xiong Quanxia Ren Yake Guo Gao Li |
| |
作者单位: | School of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology;School of Pharmacy, Shihezi University |
| |
基金项目: | the National Natural Science Foundation of China,No.81160395 |
| |
摘 要: | Carbon nanotubes can carry protein into cells to induce biological effects. Amino-functionalized carbon nanotubes are soluble and biocompatible, have high reactivity and low toxicity, and can help promote nerve cell growth. In this study, amino-functionalized ethylenediamine-treated multi-walled carbon nanotubes were used to prepare carbon nanotubes-nerve growth factor complexes by non-covalent grafting. The physicochemical properties, cytotoxicity to PC12 and chick embryo dorsal root ganglion, and biological activity of the carbon nanotubes-nerve growth factor complexes were investigated. The results showed that amino functionalization improved carbon nanotubes-nerve growth factor complex dispersibility, reduced their toxicity to PC12 cells, and promoted PC 12 cell differentiation and chick embryo dorsal root ganglion.
|
关 键 词: | 多壁碳纳米管 神经生长因子 氨基 功能化 PC12细胞 背根神经节 物理化学性质 生物效应 |
本文献已被 CNKI 维普 等数据库收录! |
|