| Graves病患者外周血淋巴细胞的IL－1／IL－2R水平及临床意义 |
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| 引用本文： | 吴汉妮,丁桂芝,沈迪. Graves病患者外周血淋巴细胞的IL－1／IL－2R水平及临床意义[J]. 中华内分泌代谢杂志, 1995, 0(1) |
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| 作者姓名： | 吴汉妮 丁桂芝 沈迪 |
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| 作者单位： | 同济医科大学附属协和医院内分泌科 |
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| 摘 要： | 测定了３０例Ｇｒａｖｅｓ病（ＧＤ）患者外周血单个核细胞的白细胞介素－２（ＩＬ－２）活性、膜ＩＬ－２受体（ｍＩＬ－２Ｒ）和可溶性ＩＬ－２受体（ｓＩＬ－２Ｒ）水平。结果发现６Ｄ患者治疗前ＩＬ－２、ｍＩＬ－２Ｒ水平显著降低，ｓＩＬ－２Ｒ水平显著升高，且与同时测定的Ｔ＿３、Ｔ＿４、ＦＴ＿４Ｉ呈显著正相关；治疗后，随着甲状腺功能的逐渐改善而相应恢复至正常范围。这些结果提示：ＧＤ患者体内存在细胞因子的免疫调节紊乱，ＩＬ－２／ＩＬ－２Ｒ水平可以反映ＧＤ免疫动态，而高甲状腺素血症与免疫细胞的激活两者之间有一定关联。
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| 关 键 词： | Graves病，白细胞介素－2，白细胞介素－2受体 |
THE STUDY OF IL-2/IL-2R OF PERIPHERAL BLOOD LYMPHOCYTESIN PATIENTS WITH GRAVES DISEASE |
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| Wu Han-ni,Ding Gui-zhi,Shen Di. THE STUDY OF IL-2/IL-2R OF PERIPHERAL BLOOD LYMPHOCYTESIN PATIENTS WITH GRAVES DISEASE[J]. Chinese Journal of Endocrinology and Metabolism, 1995, 0(1) |
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| Authors: | Wu Han-ni Ding Gui-zhi Shen Di |
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| Affiliation: | Wu Han-ni,Ding Gui-zhi,Shen DiDepartment of Endocrinology,Union Hospital,Toogji Medical University,Wuhan,430022 |
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| Abstract: | The levels of interleukin-2 (IL-2), membrane IL-2 receptor (mIL-2R) and soluble IL-2 receptor (s1L-2)of peripheral bloodmononuclear cells were measured in 30 Graves disease patients and 32 normal controls. In untreated Graves' patients IL-2 and mIL-2R levels were significantly reduced and slL-2R levels elevated as compared to normal controls (P<0. 001). A significant positivecorrelation (P
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| Keywords: | Graves disease Interleukin-2 Interleukin-2 receptor |
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