氯沙坦对自发性高血压大鼠左心室结构改变的实验研究

目的 :探讨氯沙坦 (Los)对自发性高血压大鼠 (SHR)左心室结构的影响。方法 :6周龄Los治疗组 (SHRlos)管饲法给予Los3 0mg kg天。治疗 17周后 ,观察 3组大鼠动脉收缩压 (SBP)、左心室 (LV)壁的厚度、左心室重量 体重 (LVW BW)以及左心室结构的变化 ;血浆放免法测肾素活性和AngⅡ含量。结果 :1 SBP :治疗结束后 ,SHRlos组血压 10 9 15± 11 3 1mmHg( 1mmHg =0 .13 3kPa) ,与对照组 (SHR)血压167 4± 13 0 1mmHg相比明显下降 (P <0 0 1)。 2 SHRlos组的LVW BW、LV壁厚度与SHR组相比明显减少 (P <0 0 1)。SHRlos心肌的超微结构与正常对照组 (WKY)相似。 3 血浆肾素活性在WKY组和SHR组之间无明显差异 (P >0 0 5 )。SHRlos组肾素活性及AngⅡ水平分别高于SHR组 (P <0 0 5 ,P <0 0 1)。结论 :Los能有效地降低SHR的血压 ,具有预防高血压LVH的作用。

Effects of losartan on the structure of left ventricle in spontaneously hypertensive rat

Objective:To test the effects of Los on structure of left ventricle in spontaneously hypertensive rats (SHR).Method: Los 30 mg·kg -1 ·d -1 were given in to six|week male SHRs by gavage.After 17 weeks treatment,systolic blood pressure (SBP) and left ventricle weight over body weight ration(LVW/BW) were measured.The level of LVH were assessed by means of transmission electron microscope.The plasma renin activity and Ang Ⅱ level were determined by RIA method.Result:(1) SBP in losartan|treated SHR(SHR los )(109 15±11 37 mmHg)decreased markedly compared with the untreated SHR(SHR)(167 4±13 01 mmHg)( P <0 01).(2)LVW/BW and thickness of left ventricle wall in SHR los were reduced significantly compared with SHR( P <0 01).The myocardial ultrastructure in SHR los was similar to that in WKY.(3)The differnce of plasma renin activities between WKY and SHR was not significant( P >0 05).The plasma renin activities and Ang Ⅱ level in SHR los were increased compared with SHR( P <0 05, P <0 01).Conclusion:During the development of hypertension in SHR,the blood pressure reduced and left ventricular hypertrophy was alleviated after long|term treatment with Los. [