Further insecticidal activities of essential oils from Lippia sidoides and Croton species against Aedes aegypti L. |
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Authors: | Glauber Pacelli Gomes de Lima Terezinha Maria de Souza Gabrielle de Paula Freire Davi Felipe Farias Arcelina Pacheco Cunha Nágila Maria Pontes Silva Ricardo Selene Maia de Morais Ana Fontenele Urano Carvalho |
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Institution: | 1. Department of Biochemistry and Molecular Biology, Campus Pici, Federal University of Ceara, 60455-760, Fortaleza, Ceara, Brazil 2. Department of Biology, Campus Pici, Federal University of Ceara, 60455-760, Fortaleza, Ceara, Brazil 3. Department of Organic and Inorganic Chemistry, Federal University of Ceara, 60455-760, Fortaleza, Ceara, Brazil 4. Course of Chemistry, Ceara State University, Itaperi Campus, 60740-000, Fortaleza, Ceara, Brazil
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Abstract: | This study assessed new insecticidal activities of essential oils from Lippia sidoides and Croton species (Croton zehntneri, Croton nepetaefolius, Croton argyrophylloides, and Croton sonderianus) against Aedes aegypti mosquito. In addition, the acute toxicity upon mice was determined. All essential oils showed inhibition of egg hatching, with IC50 values ranging from 66.4 to 143.2 μg?mL?1, larvicidal activity with LC50 ranging from 25.5 to 94.6 μg?mL?1, and pupicidal action with PC50 ranging from 276.8 to over 500 μg?mL?1. Only L. sidoides, C. zehntneri, and C. argyrophylloides essential oils were able to inhibit the oviposition of female gravid mosquitoes with OD50 values of 35.3, 45.3, and 45.8 μg?mL?1, respectively. Oral acute toxicity in mice showed that C. sonderianus and C. argyrophylloides oils are nontoxic (LD50?>?6,000 mg.kg?1) while C. nepetaefolius, C. zehntneri, and L. sidoides oils are moderately toxic (LD50 3,840; 3,464, and 2,624 mg.kg?1, respectively). The results indicate that these oils are promising sources of bioactive compounds, showing low or no toxicity to mammals. |
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