Impaired gallbladder function in spinal cord injury on quantitative Tc-99m DISIDA cholescintigraphy |
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Authors: | Fong Y C Hsu H C Sun S S Kao A Lin C C Lee C C |
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Institution: | (1) Department of Orthopedics, China Medical College Hospital, No. 2 Yuh-Der Road, Taichung 404, Taiwan, TW;(2) Department of Nuclear Medicine, China Medical College Hospital, No. 2 Yuh-Der Road, Taichung 404, Taiwan, TW;(3) Department of Medical Research, China Medical College Hospital, No. 2 Yuh-Der Road, Taichung 404, Taiwan, TW;(4) Department of Family Medicine, China Medical College Hospital, No. 2 Yuh-Der Road, Taichung 404, Taiwan, TW |
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Abstract: | Background: Patients with spinal cord injury (SCI) have increased prevalences of gallstones and acute acalculous cholecystitis. A possible
explanation for the increased prevalence of gallstone disease in SCI patients is decreased gallbladder motility causing gallbladder
stasis, a known risk factor for gallstone disease. We investigated gallbladder function in SCI.
Methods: Twenty-five normal control subjects and 50 SCI patients were included in this study. Gallbladder function was measured by
technium 99m–labeled imino-diacetic acid analogue (Tc-99m DISIDA) cholescintigraphy and represented by the filling fraction
(FF) and the ejection fraction (EF). The SCI patients were assigned to subgroups: old versus young, female versus male, high-
versus low-level injury, and long versus short injury duration.
Results: Forty-two percent of SCI patients had abnormal FFs and 54% of SCI patients had abnormal EFs. Significantly decreased FF and
EF values were found in SCI patients, especially in those who were female and had high-level injuries.
Conclusion: With the use of quantitative Tc-99m DISIDA cholescintigraphy, we found that SCI can significantly impair gallbladder function. |
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Keywords: | : Gallbladder function— Spinal cord injury— Technium 99m– labeled imino-diacetic acid analogue cholescintigraphy |
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